Title |
MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS
|
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Published in |
Tumor Biology, December 2015
|
DOI | 10.1007/s13277-015-4507-7 |
Pubmed ID | |
Authors |
Xin Fu, Yanfen Cui, Shaobin Yang, Yue Xu, Zicheng Zhang |
Abstract |
MicroRNAs (miRNAs) play several important roles in carcinogenesis, and the dysregulation of miRNAs is associated with cancer progression. Little is known about the role of miR-613 in ovarian cancer. In the present study, we demonstrate that miR-613 expression is downregulated in human ovarian cancer cell lines and tissues. Additionally, miR-613 overexpression suppressed ovarian cancer cell proliferation, colony formation, and invasion. Furthermore, KRAS was identified as a target of miR-613. Reintroducing KRAS rescued the inhibitory effects exerted by miR-613 on ovarian cancer cell proliferation and invasion. Taken together, our findings suggest that miR-613 functions as a candidate tumor suppressor miRNA in ovarian cancer by directly targeting KRAS. To the best of our knowledge, this is the first study to show that miR-613 affects the proliferation and invasion of ovarian cancer. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 30% |
Student > Ph. D. Student | 4 | 20% |
Other | 2 | 10% |
Student > Master | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Other | 2 | 10% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 35% |
Agricultural and Biological Sciences | 4 | 20% |
Nursing and Health Professions | 2 | 10% |
Medicine and Dentistry | 1 | 5% |
Unknown | 6 | 30% |