| Title |
Increased interhemispheric resting-state functional connectivity after sleep deprivation: a resting-state fMRI study
|
|---|---|
| Published in |
Brain Imaging and Behavior, December 2015
|
| DOI | 10.1007/s11682-015-9490-5 |
| Pubmed ID | |
| Authors |
Yuanqiang Zhu, Zhiyan Feng, Junling Xu, Chang Fu, Jinbo Sun, Xuejuan Yang, Dapeng Shi, Wei Qin |
| Abstract |
Several functional imaging studies have investigated the regional effects of sleep deprivation (SD) on impaired brain function; however, potential changes in the functional interactions between the cerebral hemispheres after SD are not well understood. In this study, we used a recently validated approach, voxel-mirrored homotopic connectivity (VMHC), to directly examine the changes in interhemispheric homotopic resting-state functional connectivity (RSFC) after SD. Resting-state functional MRI (fMRI) was performed in 28 participants both after rest wakefulness (RW) and a total night of SD. An interhemispheric RSFC map was obtained by calculating the Pearson correlation (Fisher Z transformed) between each pair of homotopic voxel time series for each subject in each condition. The between-condition differences in interhemispheric RSFC were then examined at global and voxelwise levels separately. Significantly increased global VMHC was found after sleep deprivation; specifically, a significant increase in VMHC was found in specific brain regions, including the thalamus, paracentral lobule, supplementary motor area, postcentral gyrus and lingual gyrus. No regions showed significantly reduced VMHC after sleep deprivation. Further analysis indicates that these findings did not depend on the various sizes of smoothing kernels that were adopted in the preprocessing steps and that the differences in these regions were still significant with or without global signal regression. Our data suggest that the increased VMHC might reflect the compensatory involvement of bilateral brain areas, especially the bilateral thalamus, to prevent cognitive performance deterioration when sleep pressure is elevated after sleep deprivation. Our findings provide preliminary evidence of interhemispheric correlation changes after SD and contribute to a better understanding of the neural mechanisms of SD. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 4% |
| Uruguay | 1 | 2% |
| Unknown | 49 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 13% |
| Researcher | 7 | 13% |
| Student > Master | 6 | 12% |
| Student > Postgraduate | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 11 | 21% |
| Unknown | 14 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 19% |
| Psychology | 8 | 15% |
| Medicine and Dentistry | 5 | 10% |
| Engineering | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 17 | 33% |
Attention Score in Context
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Outputs of similar age from Brain Imaging and Behavior
#20
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