| Title |
Histone deacetylase-mediated morphological transition in Candida albicans
|
|---|---|
| Published in |
Journal of Microbiology, December 2015
|
| DOI | 10.1007/s12275-015-5488-3 |
| Pubmed ID | |
| Authors |
Jueun Kim, Ji-Eun Lee, Jung-Shin Lee |
| Abstract |
Candida albicans is the most common opportunistic fungal pathogen, which switches its morphology from single-cell yeast to filament through the various signaling pathways responding to diverse environmental cues. Various transcriptional factors such as Nrg1, Efg1, Brg1, Ssn6, and Tup1 are the key components of these signaling pathways. Since C. albicans can regulate its transcriptional gene expressions using common eukaryotic regulatory systems, its morphological transition by these signaling pathways could be linked to the epigenetic regulation by chromatin structure modifiers. Histone proteins, which are critical components of eukaryotic chromatin structure, can regulate the eukaryotic chromatin structure through their own modifications such as acetylation, methylation, phosphorylation and ubiquitylation. Recent studies revealed that various histone modifications, especially histone acetylation and deacetylation, participate in morphological transition of C. albicans collaborating with well-known transcription factors in the signaling pathways. Here, we review recent studies about chromatin-mediated morphological transition of C. albicans focusing on the interaction between transcription factors in the signaling pathways and histone deacetylases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 22% |
| Student > Ph. D. Student | 6 | 19% |
| Student > Doctoral Student | 4 | 13% |
| Professor | 3 | 9% |
| Student > Bachelor | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 38% |
| Agricultural and Biological Sciences | 6 | 19% |
| Immunology and Microbiology | 5 | 16% |
| Medicine and Dentistry | 3 | 9% |
| Unspecified | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 4 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#19,495,804
of 23,975,976 outputs
Outputs from Journal of Microbiology
#564
of 842 outputs
Outputs of similar age
#288,351
of 394,798 outputs
Outputs of similar age from Journal of Microbiology
#14
of 19 outputs
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