Title |
Myosin II activity dependent and independent vinculin recruitment to the sites of E-cadherin-mediated cell-cell adhesion
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Published in |
BMC Molecular and Cell Biology, November 2011
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DOI | 10.1186/1471-2121-12-48 |
Pubmed ID | |
Authors |
Grant M Sumida, Tyler M Tomita, Wenting Shih, Soichiro Yamada |
Abstract |
Maintaining proper adhesion between neighboring cells depends on the ability of cells to mechanically respond to tension at cell-cell junctions through the actin cytoskeleton. Thus, identifying the molecules involved in responding to cell tension would provide insight into the maintenance, regulation, and breakdown of cell-cell junctions during various biological processes. Vinculin, an actin-binding protein that associates with the cadherin complex, is recruited to cell-cell contacts under increased tension in a myosin II-dependent manner. However, the precise role of vinculin at force-bearing cell-cell junctions and how myosin II activity alters the recruitment of vinculin at quiescent cell-cell contacts have not been demonstrated. |
Mendeley readers
Geographical breakdown
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France | 3 | 3% |
Unknown | 86 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
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Researcher | 24 | 26% |
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Professor | 5 | 5% |
Student > Bachelor | 4 | 4% |
Other | 11 | 12% |
Unknown | 11 | 12% |
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Physics and Astronomy | 3 | 3% |
Other | 5 | 5% |
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