| Title |
Association between genetic variants of the clock gene and obesity and sleep duration
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, November 2015
|
| DOI | 10.1007/s13105-015-0447-3 |
| Pubmed ID | |
| Authors |
Macarena Valladares, Ana María Obregón, Jean-Philippe Chaput |
| Abstract |
Obesity is a multifactorial disease caused by the interaction of genetic and environmental factors related to lifestyle aspects. It has been shown that reduced sleep is associated with increased body mass index (BMI). Circadian Locomotor Output Cycles Kaput (CLOCK) gene variants have also been associated with obesity. The objective of this mini-review was to discuss the available literature related to CLOCK gene variants associated with adiposity and sleep duration in humans. In total, 16 articles complied with the terms of the search that reported CLOCK variants associated with sleep duration, energy intake, and BMI. Overall, six CLOCK single nucleotide polymorphisms (SNPs) have been associated with sleep duration, and three variants have been associated with energy intake variables. Overall, the most studied area has been the association of CLOCK gene with obesity; close to eight common variants have been associated with obesity. The most studied CLOCK SNP in different populations is rs1801260, and most of these populations correspond to European populations. Collectively, identifying at risk CLOCK genotypes is a new area of research that may help identify individuals who are more susceptible to overeating and gaining weight when exposed to short sleep durations. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 17% |
| Researcher | 15 | 15% |
| Student > Ph. D. Student | 13 | 13% |
| Student > Doctoral Student | 9 | 9% |
| Student > Postgraduate | 7 | 7% |
| Other | 18 | 17% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Medicine and Dentistry | 20 | 19% |
| Nursing and Health Professions | 9 | 9% |
| Agricultural and Biological Sciences | 7 | 7% |
| Chemistry | 3 | 3% |
| Other | 16 | 16% |
| Unknown | 28 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2015.
All research outputs
#13,451,339
of 22,834,308 outputs
Outputs from Journal of Physiology and Biochemistry
#227
of 529 outputs
Outputs of similar age
#133,792
of 282,790 outputs
Outputs of similar age from Journal of Physiology and Biochemistry
#3
of 8 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 529 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 53% of its peers.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.