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Genomic Insights into the Ancestry and Demographic History of South America

Overview of attention for article published in PLoS Genetics, December 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
104 X users
facebook
2 Facebook pages
wikipedia
49 Wikipedia pages
googleplus
2 Google+ users

Citations

dimensions_citation
196 Dimensions

Readers on

mendeley
345 Mendeley
citeulike
5 CiteULike
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Title
Genomic Insights into the Ancestry and Demographic History of South America
Published in
PLoS Genetics, December 2015
DOI 10.1371/journal.pgen.1005602
Pubmed ID
Authors

Julian R. Homburger, Andrés Moreno-Estrada, Christopher R. Gignoux, Dominic Nelson, Elena Sanchez, Patricia Ortiz-Tello, Bernardo A. Pons-Estel, Eduardo Acevedo-Vasquez, Pedro Miranda, Carl D. Langefeld, Simon Gravel, Marta E. Alarcón-Riquelme, Carlos D. Bustamante

Abstract

South America has a complex demographic history shaped by multiple migration and admixture events in pre- and post-colonial times. Settled over 14,000 years ago by Native Americans, South America has experienced migrations of European and African individuals, similar to other regions in the Americas. However, the timing and magnitude of these events resulted in markedly different patterns of admixture throughout Latin America. We use genome-wide SNP data for 437 admixed individuals from 5 countries (Colombia, Ecuador, Peru, Chile, and Argentina) to explore the population structure and demographic history of South American Latinos. We combined these data with population reference panels from Africa, Asia, Europe and the Americas to perform global ancestry analysis and infer the subcontinental origin of the European and Native American ancestry components of the admixed individuals. By applying ancestry-specific PCA analyses we find that most of the European ancestry in South American Latinos is from the Iberian Peninsula; however, many individuals trace their ancestry back to Italy, especially within Argentina. We find a strong gradient in the Native American ancestry component of South American Latinos associated with country of origin and the geography of local indigenous populations. For example, Native American genomic segments in Peruvians show greater affinities with Andean indigenous peoples like Quechua and Aymara, whereas Native American haplotypes from Colombians tend to cluster with Amazonian and coastal tribes from northern South America. Using ancestry tract length analysis we modeled post-colonial South American migration history as the youngest in Latin America during European colonization (9-14 generations ago), with an additional strong pulse of European migration occurring between 3 and 9 generations ago. These genetic footprints can impact our understanding of population-level differences in biomedical traits and, thus, inform future medical genetic studies in the region.

X Demographics

X Demographics

The data shown below were collected from the profiles of 104 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Chile 2 <1%
Germany 1 <1%
Netherlands 1 <1%
Uruguay 1 <1%
Colombia 1 <1%
Canada 1 <1%
Brazil 1 <1%
Unknown 332 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 71 21%
Researcher 59 17%
Student > Bachelor 48 14%
Student > Master 34 10%
Other 19 6%
Other 61 18%
Unknown 53 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 100 29%
Biochemistry, Genetics and Molecular Biology 87 25%
Medicine and Dentistry 29 8%
Social Sciences 17 5%
Engineering 8 2%
Other 42 12%
Unknown 62 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2024.
All research outputs
#423,927
of 25,579,912 outputs
Outputs from PLoS Genetics
#253
of 8,986 outputs
Outputs of similar age
#6,774
of 395,832 outputs
Outputs of similar age from PLoS Genetics
#6
of 201 outputs
Altmetric has tracked 25,579,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,986 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.