| Title |
Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties
|
|---|---|
| Published in |
Journal of Nanobiotechnology, September 2018
|
| DOI | 10.1186/s12951-018-0389-3 |
| Pubmed ID | |
| Authors |
Yongwei Gu, Meng Yang, Xiaomeng Tang, Ting Wang, Dishun Yang, Guangxi Zhai, Jiyong Liu |
| Abstract |
In recent years, nanoparticles (NPs) including nanostructured lipid carries (NLC) and solid lipid nanoparticles (SLN) captured an increasing amount of attention in the field of transdermal drug delivery system. However, the mechanisms of penetration enhancement and transdermal transport properties of NPs are not fully understood. Therefore, this work applied different platforms to evaluate the interactions between skin and NPs loading triptolide (TPL, TPL-NLC and TPL-SLN). Besides, NPs labeled with fluorescence probe were tracked after administration to investigate the dynamic penetration process in skin and skin cells. In addition, ELISA assay was applied to verify the in vitro anti-inflammatory effect of TPL-NPs. Compared with the control group, TPL-NPs could disorder skin structure, increase keratin enthalpy and reduce the SC infrared absorption peak area. Besides, the work found that NPs labeled with fluorescence probe accumulated in hair follicles and distributed throughout the skin after 1 h of administration and were taken into HaCaT cells cytoplasm by transcytosis. Additionally, TPL-NLC could effectively inhibit the expression of IL-4, IL-6, IL-8, IFN-γ, and MCP-1 in HaCaT cells, while TPL-SLN and TPL solution can only inhibit the expression of IL-6. TPL-NLC and TPL-SLN could penetrate into skin in a time-dependent manner and the penetration is done by changing the structure, thermodynamic properties and components of the SC. Furthermore, the significant anti-inflammatory effect of TPL-NPs indicated that nanoparticles containing NLC and SLN could serve as safe prospective agents for transdermal drug delivery system. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 14% |
| Student > Bachelor | 8 | 10% |
| Student > Ph. D. Student | 7 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Student > Postgraduate | 4 | 5% |
| Other | 12 | 14% |
| Unknown | 37 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 30 | 36% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Medicine and Dentistry | 4 | 5% |
| Nursing and Health Professions | 1 | 1% |
| Agricultural and Biological Sciences | 1 | 1% |
| Other | 6 | 7% |
| Unknown | 38 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2018.
All research outputs
#14,425,183
of 23,103,436 outputs
Outputs from Journal of Nanobiotechnology
#515
of 1,456 outputs
Outputs of similar age
#189,548
of 337,900 outputs
Outputs of similar age from Journal of Nanobiotechnology
#19
of 24 outputs
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So far Altmetric has tracked 1,456 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.