| Title |
Nodding syndrome in Uganda is a tauopathy
|
|---|---|
| Published in |
Acta Neuropathologica, September 2018
|
| DOI | 10.1007/s00401-018-1909-9 |
| Pubmed ID | |
| Authors |
Michael S. Pollanen, Sylvester Onzivua, Janice Robertson, Paul M. McKeever, Francis Olawa, David L. Kitara, Amanda Fong |
| Abstract |
Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic examination revealed tau-immunoreactive neuronal neurofibrillary tangles, pre-tangles, neuropil threads, and dot-like lesions involving the cerebral cortex, subcortical nuclei and brainstem. There was preferential involvement of the frontal and temporal lobes in a patchy distribution, mostly involving the crests of gyri and the superficial cortical lamina. The mesencephalopontine tegmental nuclei, substantia nigra, and locus coeruleus revealed globose neurofibrillary tangles and threads. We conclude that nodding syndrome is a tauopathy and may represent a newly recognized neurodegenerative disease. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 13% |
| Spain | 2 | 9% |
| Austria | 1 | 4% |
| Venezuela, Bolivarian Republic of | 1 | 4% |
| Serbia | 1 | 4% |
| Colombia | 1 | 4% |
| United States | 1 | 4% |
| Chile | 1 | 4% |
| Unknown | 12 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 57% |
| Practitioners (doctors, other healthcare professionals) | 5 | 22% |
| Scientists | 4 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 15% |
| Researcher | 6 | 11% |
| Student > Bachelor | 6 | 11% |
| Student > Postgraduate | 5 | 9% |
| Other | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 15 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 19% |
| Medicine and Dentistry | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Social Sciences | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 20 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2019.
All research outputs
#1,032,933
of 25,378,162 outputs
Outputs from Acta Neuropathologica
#153
of 2,526 outputs
Outputs of similar age
#22,033
of 349,954 outputs
Outputs of similar age from Acta Neuropathologica
#4
of 32 outputs
Altmetric has tracked 25,378,162 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,526 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.