| Title |
Superoxide Formation in Cardiac Mitochondria and Effect of Phenolic Antioxidants
|
|---|---|
| Published in |
Cell Biochemistry and Biophysics, September 2018
|
| DOI | 10.1007/s12013-018-0857-2 |
| Pubmed ID | |
| Authors |
Arina L. Dudylina, Marina V. Ivanova, Konstantin B. Shumaev, Enno K. Ruuge |
| Abstract |
Since mitochondria are the main cellular source of reactive oxygen species, it is important to study the effect of dietary phenolic compounds on the level of ROS in these organelles. Using the EPR spectroscopy and TIRON probe, the ability of the investigated phenols (quercetin, rutin, caffeic acid, curcumin, and resveratrol) to scavenge superoxide anion radicals generated by isolated heart mitochondria of Wistar rats under variable oxygen partial pressure was studied. It was shown that during a 10 min incubation, caffeic acid in concentrations of 10-500 μM most effectively scavenged superoxide radicals formed in the complex III of the mitochondrial respiratory chain. A comparable antioxidant effect of rutin under these experimental conditions was observed at higher concentrations of 1-10 mM. The antioxidant activity of quercetin in the concentration range of 10-500 μM during the first minutes of incubation was higher than that of caffeic acid. Of the phenolic compounds studied, curcumin had the least effect on the superoxide radicals. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 18 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Bachelor | 2 | 11% |
| Professor > Associate Professor | 1 | 6% |
| Unknown | 11 | 61% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Arts and Humanities | 1 | 6% |
| Nursing and Health Professions | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 10 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2018.
All research outputs
#18,649,291
of 23,103,436 outputs
Outputs from Cell Biochemistry and Biophysics
#481
of 918 outputs
Outputs of similar age
#258,957
of 337,432 outputs
Outputs of similar age from Cell Biochemistry and Biophysics
#4
of 5 outputs
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So far Altmetric has tracked 918 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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