| Title |
Sex and age interact to determine clinicopathologic differences in Alzheimer’s disease
|
|---|---|
| Published in |
Acta Neuropathologica, September 2018
|
| DOI | 10.1007/s00401-018-1908-x |
| Pubmed ID | |
| Authors |
Amanda M. Liesinger, Neill R. Graff-Radford, Ranjan Duara, Rickey E. Carter, Fadi S. Hanna Al-Shaikh, Shunsuke Koga, Kelly M. Hinkle, Sarah K. DiLello, McKenna F. Johnson, Adel Aziz, Nilufer Ertekin-Taner, Owen A. Ross, Dennis W. Dickson, Melissa E. Murray |
| Abstract |
Women reportedly make up two-thirds of Alzheimer's disease (AD) dementia sufferers. Many estimates regarding AD, however, are based on clinical series lacking autopsy confirmation. The Florida Autopsied Multi-Ethnic (FLAME) cohort was queried for AD cases with a total of 1625 identified ranging in age from 53 to 102 years at death. Standard neuropathologic procedures were employed and clinical information was retrospectively collected. Clinicopathologic and genetic data (MAPT and APOE) were stratified by sex. Within the neuropathologically diagnosed AD cohort, the overall number of women and men did not differ. Men were younger at onset of cognitive symptoms, had a shorter disease duration, and more often had atypical (non-amnestic) clinical presentations. The frequency of autopsy-confirmed AD among women and men stratified by age at death revealed an inverse U-shaped curve in men and a U-shaped curve in women, with both curves having inflections at approximately 70 years of age. Regional counts of neurofibrillary tangles differed in women and men, especially when examined by age intervals. Women had overall greater severity of neurofibrillary tangle counts compared to men, especially in the hippocampus. Men were more often classified as hippocampal sparing AD, whereas limbic predominant AD was more common in women. Men and women did not differ in frequency of MAPT haplotype or APOE genotype. Atypical clinical presentations, younger age at onset and shorter disease duration were more frequent in men, suggesting that the lower reported frequency of AD in men may be due to more frequent atypical clinical presentations not recognized as AD. Our data suggest that neuropathologically diagnosed AD cases have the same frequency of women and men, but their clinical presentations and ages at onset tend to differ. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Spain | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 40% |
| Members of the public | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 13% |
| Student > Ph. D. Student | 10 | 13% |
| Researcher | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Professor | 6 | 8% |
| Other | 16 | 21% |
| Unknown | 22 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 22% |
| Medicine and Dentistry | 11 | 14% |
| Psychology | 8 | 10% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 23 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2021.
All research outputs
#2,076,881
of 25,050,563 outputs
Outputs from Acta Neuropathologica
#465
of 2,514 outputs
Outputs of similar age
#42,191
of 343,549 outputs
Outputs of similar age from Acta Neuropathologica
#10
of 32 outputs
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