| Title |
The Effects of Probiotic Honey Consumption on Metabolic Status in Patients with Diabetic Nephropathy: a Randomized, Double-Blind, Controlled Trial
|
|---|---|
| Published in |
Probiotics and Antimicrobial Proteins, September 2018
|
| DOI | 10.1007/s12602-018-9468-x |
| Pubmed ID | |
| Authors |
Navid Mazruei Arani, Zahra Emam-Djomeh, Hamid Tavakolipour, Reza Sharafati-Chaleshtori, Alireza Soleimani, Zatollah Asemi |
| Abstract |
To the best of our knowledge, this study is the first evaluating the effects of probiotic honey intake on glycemic control, lipid profiles, biomarkers of inflammation, and oxidative stress in patients with diabetic nephropathy (DN). This investigation was conducted to evaluate the effects of probiotic honey intake on metabolic status in patients with DN. This randomized, double-blind, controlled clinical trial was performed among 60 patients with DN. Patients were randomly allocated into two groups to receive either 25 g/day probiotic honey containing a viable and heat-resistant probiotic Bacillus coagulans T11 (IBRC-M10791) (108 CFU/g) or 25 g/day control honey (n = 30 each group) for 12 weeks. Fasting blood samples were taken at baseline and 12 weeks after supplementation to quantify glycemic status, lipid concentrations, biomarkers of inflammation, and oxidative stress. After 12 weeks of intervention, patients who received probiotic honey compared with the control honey had significantly decreased serum insulin levels (- 1.2 ± 1.8 vs. - 0.1 ± 1.3 μIU/mL, P = 0.004) and homeostasis model of assessment-estimated insulin resistance (- 0.5 ± 0.6 vs. 0.003 ± 0.4, P = 0.002) and significantly improved quantitative insulin sensitivity check index (+ 0.005 ± 0.009 vs. - 0.0007 ± 0.005, P = 0.004). Additionally, compared with the control honey, probiotic honey intake has resulted in a significant reduction in total-/HDL-cholesterol (- 0.2 ± 0.5 vs. + 0.1 ± 0.1, P = 0.04). Probiotic honey intake significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (- 1.9 ± 2.4 vs. - 0.2 ± 2.7 mg/L, P = 0.01) and plasma malondialdehyde (MDA) levels (- 0.1 ± 0.6 vs. + 0.6 ± 1.0 μmol/L, P = 0.002) compared with the control honey. Probiotic honey intake had no significant effects on other metabolic profiles compared with the control honey. Overall, findings from the current study demonstrated that probiotic honey consumption for 12 weeks among DN patients had beneficial effects on insulin metabolism, total-/HDL-cholesterol, serum hs-CRP, and plasma MDA levels, but did not affect other metabolic profiles. http://www.irct.ir : IRCT201705035623N115. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 119 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 13% |
| Other | 10 | 8% |
| Researcher | 7 | 6% |
| Student > Doctoral Student | 7 | 6% |
| Student > Master | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 61 | 51% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 18% |
| Nursing and Health Professions | 11 | 9% |
| Agricultural and Biological Sciences | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Neuroscience | 4 | 3% |
| Other | 5 | 4% |
| Unknown | 66 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2018.
All research outputs
#15,545,423
of 23,103,436 outputs
Outputs from Probiotics and Antimicrobial Proteins
#238
of 548 outputs
Outputs of similar age
#213,251
of 337,432 outputs
Outputs of similar age from Probiotics and Antimicrobial Proteins
#7
of 20 outputs
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So far Altmetric has tracked 548 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
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