| Title |
Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes
|
|---|---|
| Published in |
Molecular Medicine, October 2015
|
| DOI | 10.2119/molmed.2015.00067 |
| Pubmed ID | |
| Authors |
Sho-ichi Yamagishi, Nobutaka Nakamura, Mika Suematsu, Kuniyoshi Kaseda, Takanori Matsui |
| Abstract |
A nonenzymatic reaction between reducing sugars and amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and subsequently alters their structural integrity and function. This process has been known to progress at an accelerated rate under hyperglycemic and/or oxidative stress conditions. Over a course of days to weeks, early glycation products undergo further reactions such as rearrangements and dehydration to become irreversibly cross-linked, fluorescent and senescent macroprotein derivatives termed advanced glycation end products (AGEs). There is a growing body of evidence indicating that interaction of AGEs with their receptor (RAGE) elicits oxidative stress generation and as a result evokes proliferative, inflammatory, thrombotic and fibrotic reactions in a variety of cells. This evidence supports AGEs' involvement in diabetes- and aging-associated disorders such as diabetic vascular complications, cancer, Alzheimer's disease and osteoporosis. Therefore, inhibition of AGE formation could be a novel molecular target for organ protection in diabetes. This report summarizes the pathophysiological role of AGEs in vascular complications in diabetes and discusses the potential clinical utility of measurement of serum levels of AGEs for evaluating organ damage in diabetes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Japan | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | <1% |
| China | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 16% |
| Student > Bachelor | 17 | 14% |
| Researcher | 12 | 10% |
| Student > Ph. D. Student | 12 | 10% |
| Student > Postgraduate | 7 | 6% |
| Other | 15 | 12% |
| Unknown | 39 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 24% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Agricultural and Biological Sciences | 10 | 8% |
| Immunology and Microbiology | 4 | 3% |
| Nursing and Health Professions | 3 | 2% |
| Other | 16 | 13% |
| Unknown | 43 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2021.
All research outputs
#4,457,146
of 22,834,308 outputs
Outputs from Molecular Medicine
#170
of 1,138 outputs
Outputs of similar age
#61,519
of 284,532 outputs
Outputs of similar age from Molecular Medicine
#3
of 19 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,138 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.