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Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, December 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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1 news outlet
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7 X users

Citations

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175 Dimensions

Readers on

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212 Mendeley
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Title
Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa
Published in
Antimicrobial Agents and Chemotherapy, December 2015
DOI 10.1128/aac.02379-15
Pubmed ID
Authors

Krystyna M. Kazmierczak, Sharon Rabine, Meredith Hackel, Robert E. McLaughlin, Douglas J. Biedenbach, Samuel K. Bouchillon, Daniel F. Sahm, Patricia A. Bradford

Abstract

Metallo-β-lactamases (MBLs) hydrolyze all classes of β-lactams except monobactams and are not inhibited by classic serine β-lactamase inhibitors. Gram-negative pathogens isolated from patient infections were collected from 202 medical centers in 40 countries as part of a global surveillance study in 2012-2014. Carbapenem non-susceptible Enterobacteriaceae and Pseudomonas aeruginosa were characterized for bla genes encoding VIM, IMP, NDM, SPM, and GIM variants using PCR and sequencing. 471 MBL-positive isolates included the following species (number): P. aeruginosa (308), Klebsiella spp. (85), Enterobacter spp. (39), Proteeae (16), Citrobacter freundii (12), Escherichia coli (6), and Serratia marcescens (5) and were submitted by sites from 34 countries. Of these, 69.6% were collected in 9 countries (number): Russia (72), Greece (61), the Philippines (54), Venezuela (29), and 20-25 isolates each from Kuwait, Nigeria, Romania, South Africa, and Thailand. Thirty-two different MBL variants were detected (14 VIM, 14 IMP, 4 NDM). Seven novel MBL variants were encountered in the study, each differing from a previously reported variant by one amino acid substitution: VIM-42 (VIM-1 [V223I]), VIM-43 (VIM-4 [A24V]), VIM-44 (VIM-2 [K257N]), VIM-45 (VIM-2 [T35I]), IMP-48 (IMP-14 [I69T]), IMP-49 (IMP-18 [V49F]) and NDM-16 (NDM-1 [R264H]). The in vitro activities of all tested antibiotics against MBL-positive Enterobacteriaceae were significantly reduced with the exception of aztreonam-avibactam (MIC90 0.5-1 μg/mL), whereas colistin was the most effective agent against MBL-positive P. aeruginosa (>97% susceptible). Although the global percentage of isolates encoding MBLs remains relatively low, their detection in twelve species, 34 countries, and all regions participating in this surveillance study is concerning.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Norway 1 <1%
Unknown 209 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 13%
Researcher 27 13%
Student > Master 27 13%
Student > Bachelor 22 10%
Other 14 7%
Other 44 21%
Unknown 51 24%
Readers by discipline Count As %
Immunology and Microbiology 34 16%
Medicine and Dentistry 30 14%
Biochemistry, Genetics and Molecular Biology 30 14%
Agricultural and Biological Sciences 15 7%
Pharmacology, Toxicology and Pharmaceutical Science 14 7%
Other 27 13%
Unknown 62 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2016.
All research outputs
#2,759,690
of 25,371,288 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#1,561
of 15,579 outputs
Outputs of similar age
#44,177
of 395,318 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#40
of 214 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,579 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 214 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.