Title |
European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update
|
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Published in |
Annals of the Rheumatic Diseases, December 2015
|
DOI | 10.1136/annrheumdis-2015-208337 |
Pubmed ID | |
Authors |
L Gossec, J S Smolen, S Ramiro, M de Wit, M Cutolo, M Dougados, P Emery, R Landewé, S Oliver, D Aletaha, N Betteridge, J Braun, G Burmester, J D Cañete, N Damjanov, O FitzGerald, E Haglund, P Helliwell, T K Kvien, R Lories, T Luger, M Maccarone, H Marzo-Ortega, D McGonagle, I B McInnes, I Olivieri, K Pavelka, G Schett, J Sieper, F van den Bosch, D J Veale, J Wollenhaupt, A Zink, D van der Heijde |
Abstract |
Since the publication of the European League Against Rheumatism recommendations for the pharmacological treatment of psoriatic arthritis (PsA) in 2012, new evidence and new therapeutic agents have emerged. The objective was to update these recommendations. A systematic literature review was performed regarding pharmacological treatment in PsA. Subsequently, recommendations were formulated based on the evidence and the expert opinion of the 34 Task Force members. Levels of evidence and strengths of recommendations were allocated. The updated recommendations comprise 5 overarching principles and 10 recommendations, covering pharmacological therapies for PsA from non-steroidal anti-inflammatory drugs (NSAIDs), to conventional synthetic (csDMARD) and biological (bDMARD) disease-modifying antirheumatic drugs, whatever their mode of action, taking articular and extra-articular manifestations of PsA into account, but focusing on musculoskeletal involvement. The overarching principles address the need for shared decision-making and treatment objectives. The recommendations address csDMARDs as an initial therapy after failure of NSAIDs and local therapy for active disease, followed, if necessary, by a bDMARD or a targeted synthetic DMARD (tsDMARD). The first bDMARD would usually be a tumour necrosis factor (TNF) inhibitor. bDMARDs targeting interleukin (IL)12/23 (ustekinumab) or IL-17 pathways (secukinumab) may be used in patients for whom TNF inhibitors are inappropriate and a tsDMARD such as a phosphodiesterase 4-inhibitor (apremilast) if bDMARDs are inappropriate. If the first bDMARD strategy fails, any other bDMARD or tsDMARD may be used. These recommendations provide stakeholders with an updated consensus on the pharmacological treatment of PsA and strategies to reach optimal outcomes in PsA, based on a combination of evidence and expert opinion. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 13 | 19% |
Spain | 8 | 12% |
Ireland | 5 | 7% |
United States | 4 | 6% |
Colombia | 3 | 4% |
Mexico | 3 | 4% |
Italy | 2 | 3% |
Turkey | 2 | 3% |
Germany | 2 | 3% |
Other | 9 | 13% |
Unknown | 16 | 24% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 42 | 63% |
Practitioners (doctors, other healthcare professionals) | 10 | 15% |
Science communicators (journalists, bloggers, editors) | 8 | 12% |
Scientists | 7 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 2 | <1% |
Brazil | 2 | <1% |
United Kingdom | 2 | <1% |
Netherlands | 1 | <1% |
Germany | 1 | <1% |
Finland | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Other | 0 | 0% |
Unknown | 610 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 97 | 16% |
Other | 92 | 15% |
Student > Master | 72 | 12% |
Student > Ph. D. Student | 70 | 11% |
Student > Postgraduate | 41 | 7% |
Other | 124 | 20% |
Unknown | 126 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 304 | 49% |
Pharmacology, Toxicology and Pharmaceutical Science | 36 | 6% |
Biochemistry, Genetics and Molecular Biology | 27 | 4% |
Agricultural and Biological Sciences | 16 | 3% |
Immunology and Microbiology | 13 | 2% |
Other | 77 | 12% |
Unknown | 149 | 24% |