| Title |
Capsule endoscopy findings for the diagnosis of Crohn’s disease: a nationwide case–control study
|
|---|---|
| Published in |
Journal of Gastroenterology, September 2018
|
| DOI | 10.1007/s00535-018-1507-6 |
| Pubmed ID | |
| Authors |
Motohiro Esaki, Takayuki Matsumoto, Naoki Ohmiya, Ema Washio, Toshifumi Morishita, Kei Sakamoto, Hiroo Abe, Shojiro Yamamoto, Tetsu Kinjo, Kazutomo Togashi, Kenji Watanabe, Fumihito Hirai, Masanao Nakamura, Sadaharu Nouda, Shinya Ashizuka, Teppei Omori, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Takanari Kitazono, Fukunori Kinjo, Mamoru Watanabe, Toshiyuki Matsui, Yasuo Suzuki |
| Abstract |
Capsule endoscopy can be used to identify the early stage of small bowel Crohn's disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 15% |
| Researcher | 6 | 12% |
| Student > Postgraduate | 6 | 12% |
| Student > Bachelor | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 18 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 37% |
| Engineering | 3 | 6% |
| Environmental Science | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Computer Science | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 24 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2020.
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#18,649,291
of 23,103,436 outputs
Outputs from Journal of Gastroenterology
#862
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#259,278
of 337,900 outputs
Outputs of similar age from Journal of Gastroenterology
#9
of 15 outputs
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