| Title |
Alzheimer’s disease: An exacerbation of senile phenoptosis
|
|---|---|
| Published in |
Biochemistry, December 2015
|
| DOI | 10.1134/s0006297915120056 |
| Pubmed ID | |
| Authors |
N. K. Isaev, E. V. Stelmashook, E. E. Genrikhs, M. V. Oborina, M. R. Kapkaeva, V. P. Skulachev |
| Abstract |
Alzheimer's disease is characterized by progressive memory loss and cognitive decline accompanied by degeneration of neuronal synapses, massive loss of neurons in the brain, eventually resulting in complete degradation of personality and death. Currently, the cause of the disease is not fully understood, but it is believed that the person's age is the major risk factor for development of Alzheimer's disease. People who have survived after cerebral stroke or traumatic brain injury have substantially increased risk of developing Alzheimer's disease. Social exclusion, low social activity, physical inactivity, poor mental performance, and low level of education are among risk factors for development of this neurodegenerative disease, which is consistent with the concept of phenoptosis (Skulachev, V. P., et al. (1999) Biochemistry (Moscow), 64, 1418-1426; Skulachev, M. V., and Skulachev, V. P. (2014) Biochemistry (Moscow), 79, 977-993) stating that rate of aging is related to psychological and social aspects in human behavior. Here we assumed that Alzheimer's disease might be considered as an exacerbation of senile phenoptosis. If so, then development of this disease could be slowed using mitochondria-targeted antioxidants due to the accumulated data demonstrating a link between mitochondrial dysfunction and oxidative stress both with normal aging and Alzheimer's disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 18% |
| Other | 8 | 16% |
| Student > Master | 6 | 12% |
| Researcher | 5 | 10% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 14 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 14% |
| Psychology | 7 | 14% |
| Nursing and Health Professions | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Sports and Recreations | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 16 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2015.
All research outputs
#3,710,309
of 25,374,647 outputs
Outputs from Biochemistry
#1,174
of 22,288 outputs
Outputs of similar age
#59,260
of 394,848 outputs
Outputs of similar age from Biochemistry
#11
of 141 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,288 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.