| Title |
The impact of maternal gestational weight gain on cardiometabolic risk factors in children
|
|---|---|
| Published in |
Diabetologia, September 2018
|
| DOI | 10.1007/s00125-018-4724-x |
| Pubmed ID | |
| Authors |
Claudia H. T. Tam, Ronald C. W. Ma, Lai Yuk Yuen, Risa Ozaki, Albert Martin Li, Yong Hou, Michael H. M. Chan, Chung Shun Ho, Xilin Yang, Juliana C. N. Chan, Wing Hung Tam |
| Abstract |
Accumulating evidence suggests an impact of gestational weight gain (GWG) on pregnancy outcomes; however, data on cardiometabolic risk factors later in life have not been comprehensively studied. This study aimed to evaluate the relationship between GWG and cardiometabolic risk in offspring aged 7 years. We included a total of 905 mother-child pairs who enrolled in the follow-up visit of the multicentre Hyperglycemia and Adverse Pregnancy Outcome study, at the Hong Kong Centre. Women were classified as having gained weight below, within or exceeding the 2009 Institute of Medicine (IOM) guidelines. A standardised GWG according to pre-pregnancy BMI categories was calculated to explore for any quadratic relationship. Independent of pre-pregnancy BMI, gestational hyperglycaemia and other confounders, women who gained more weight than the IOM recommendations had offspring with a larger body size and increased odds of adiposity, hypertension and insulin resistance (range of p values of all the traits: 4.6 × 10-9 < p < 0.0390) than women who were within the recommended range of weight gain during pregnancy. Meanwhile, women who gained less weight than outlined in the recommendations had offspring with increased risks of hypertension and insulin resistance, compared with those who gained weight within the recommended range (7.9 × 10-3 < p < 0.0477). Quadratic relationships for diastolic blood pressure, AUC for insulin, pancreatic beta cell function and insulin sensitivity index were confirmed in the analysis of standardised GWG (1.4 × 10-3 < pquadratic < 0.0282). Further adjustment for current BMI noticeably attenuated the observed associations. Both excessive and inadequate GWG have independent and significant impacts on childhood adiposity, hypertension and insulin resistance. Our findings support the notion that adverse intrauterine exposures are associated with persistent cardiometabolic risk in the offspring. |
X Demographics
The data shown below were collected from the profiles of 99 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 24 | 24% |
| United States | 6 | 6% |
| France | 4 | 4% |
| Australia | 4 | 4% |
| Canada | 4 | 4% |
| Spain | 4 | 4% |
| Hong Kong | 3 | 3% |
| Chile | 3 | 3% |
| Lebanon | 2 | 2% |
| Other | 15 | 15% |
| Unknown | 30 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 52 | 53% |
| Scientists | 29 | 29% |
| Practitioners (doctors, other healthcare professionals) | 16 | 16% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 13% |
| Student > Bachelor | 13 | 12% |
| Researcher | 10 | 9% |
| Student > Ph. D. Student | 8 | 7% |
| Student > Doctoral Student | 7 | 6% |
| Other | 23 | 21% |
| Unknown | 35 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 24% |
| Nursing and Health Professions | 23 | 21% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Agricultural and Biological Sciences | 3 | 3% |
| Sports and Recreations | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 40 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 744. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2020.
All research outputs
#27,154
of 25,724,500 outputs
Outputs from Diabetologia
#23
of 5,376 outputs
Outputs of similar age
#499
of 352,037 outputs
Outputs of similar age from Diabetologia
#1
of 64 outputs
Altmetric has tracked 25,724,500 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,037 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.