Title |
Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease
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Published in |
Journal of neurology, neurosurgery and psychiatry, December 2015
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DOI | 10.1136/jnnp-2015-311743 |
Pubmed ID | |
Authors |
Christian Lechner, Matthias Baumann, Eva-Maria Hennes, Kathrin Schanda, Klaus Marquard, Michael Karenfort, Steffen Leiz, Daniela Pohl, Sunita Venkateswaran, Martin Pritsch, Johannes Koch, Mareike Schimmel, Martin Häusler, Andrea Klein, Astrid Blaschek, Charlotte Thiels, Thomas Lücke, Ursula Gruber-Sedlmayr, Barbara Kornek, Andreas Hahn, Frank Leypoldt, Torsten Sandrieser, Helge Gallwitz, Johannes Stoffels, Christoph Korenke, Markus Reindl, Kevin Rostásy |
Abstract |
To determine the frequency and clinical-radiological associations of antibodies to myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) in children presenting with neuromyelitis optica (NMO) and limited forms. Children with a first event of NMO, recurrent (RON), bilateral ON (BON), longitudinally extensive transverse myelitis (LETM) or brainstem syndrome (BS) with a clinical follow-up of more than 12 months were enrolled. Serum samples were tested for MOG- and AQP4-antibodies using live cell-based assays. 45 children with NMO (n=12), LETM (n=14), BON (n=6), RON (n=12) and BS (n=1) were included. 25/45 (56%) children had MOG-antibodies at initial presentation (7 NMO, 4 BON, 8 ON, 6 LETM). 5/45 (11%) children showed AQP4-antibodies (3 NMO, 1 LETM, 1 BS) and 15/45 (33%) were seronegative for both antibodies (2 NMO, 2 BON, 4 RON, 7 LETM). No differences were found in the age at presentation, sex ratio, frequency of oligoclonal bands or median EDSS at last follow-up between the three groups. Children with MOG-antibodies more frequently (1) had a monophasic course (p=0.018) after one year, (2) presented with simultaneous ON and LETM (p=0.004) and (3) were less likely to receive immunosuppressive therapies (p=0.0002). MRI in MOG-antibody positive patients (4) less frequently demonstrated periependymal lesions (p=0.001), (5) more often were unspecific (p=0.004) and (6) resolved more frequently (p=0.016). 67% of all children presenting with NMO or limited forms tested positive for MOG- or AQP4-antibodies. MOG-antibody positivity was associated with distinct features. We therefore recommend to measure both antibodies in children with demyelinating syndromes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 38% |
France | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 15% |
Other | 10 | 14% |
Student > Ph. D. Student | 6 | 8% |
Student > Postgraduate | 5 | 7% |
Student > Doctoral Student | 5 | 7% |
Other | 12 | 16% |
Unknown | 24 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 33% |
Neuroscience | 11 | 15% |
Agricultural and Biological Sciences | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Immunology and Microbiology | 1 | 1% |
Other | 9 | 12% |
Unknown | 23 | 32% |