Title |
Recent advances in applying nanotechnologies for cancer immunotherapy
|
---|---|
Published in |
Journal of Controlled Release, September 2018
|
DOI | 10.1016/j.jconrel.2018.09.010 |
Pubmed ID | |
Authors |
Reza Mahjub, Sukhdeep Jatana, Suen Ern Lee, Zhu Qin, Griffin Pauli, Meysam Soleimani, Soheil Madadi, Shyh-Dar Li |
Abstract |
Cancer immunotherapy aimed at boosting cancer-specific immunoresponses to eradicate tumor cells has evolved as a new treatment modality. Nanoparticles incorporating antigens and immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance antitumor immunity. The nanotechnology approach has been demonstrated to be superior to standard formulations in in-vivo settings. In this article, we focus on recent advances made within the last 5 years in nanoparticle-based cancer immunotherapy, including peptide- and nucleic acid-based nanovaccines, nanomedicines containing an immunoadjuvant to activate antitumor immunity, nanoparticle delivery of immune checkpoint inhibitors and the combination of the above approaches. Encouraging results and new emerging nanotechnologies in drug delivery promise the continuous growth of this field and ultimately clinical translation of enhanced immunotherapy of cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Portugal | 1 | 20% |
France | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 98 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 20% |
Student > Ph. D. Student | 15 | 15% |
Student > Bachelor | 12 | 12% |
Researcher | 12 | 12% |
Other | 4 | 4% |
Other | 8 | 8% |
Unknown | 27 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 12% |
Biochemistry, Genetics and Molecular Biology | 9 | 9% |
Agricultural and Biological Sciences | 7 | 7% |
Chemistry | 7 | 7% |
Immunology and Microbiology | 6 | 6% |
Other | 17 | 17% |
Unknown | 40 | 41% |