| Title |
Osteoblastic Factors in Prostate Cancer Bone Metastasis
|
|---|---|
| Published in |
Current Osteoporosis Reports, September 2018
|
| DOI | 10.1007/s11914-018-0480-6 |
| Pubmed ID | |
| Authors |
Song-Chang Lin, Li-Yuan Yu-Lee, Sue-Hwa Lin |
| Abstract |
Prostate cancer bone metastasis is the lethal progression of the disease. The disease frequently presents with osteoblastic lesions in bone. The tumor-induced bone can cause complications that significantly hamper the quality of life of patients. A better understanding of how prostate cancer induces aberrant bone formation and how the aberrant bone affects the progression and treatment of the disease may improve the therapies for this disease. Prostate cancer-induced bone was shown to enhance tumor growth and confer therapeutic resistance in bone metastasis. Clinically, Radium-223, an alpha emitter that selectively targets bone, was shown to improve overall survival in patients, supporting a role of tumor-induced bone in prostate cancer progression in bone. Recently, it was discovered that PCa-induced aberrant bone formation is due, in part, from tumor-associated endothelial cells that were converted into osteoblasts through endothelial-to-osteoblast (EC-to-OSB) conversion by tumor-secreted BMP4. The unique bone-forming phenotype of prostate cancer bone metastasis plays a role in prostate cancer progression in bone and therapy resistance. Therapies that incorporate targeting the tumor-induced osteoblasts or EC-to-OSB conversion mechanism may reduce tumor-induced bone formation and improve therapy outcomes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 17% |
| Researcher | 9 | 15% |
| Student > Master | 9 | 15% |
| Student > Bachelor | 7 | 12% |
| Student > Doctoral Student | 4 | 7% |
| Other | 8 | 13% |
| Unknown | 13 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 27% |
| Medicine and Dentistry | 13 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
| Materials Science | 3 | 5% |
| Agricultural and Biological Sciences | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 15 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#18,649,666
of 23,103,903 outputs
Outputs from Current Osteoporosis Reports
#405
of 551 outputs
Outputs of similar age
#258,917
of 337,288 outputs
Outputs of similar age from Current Osteoporosis Reports
#12
of 17 outputs
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