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Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study

Overview of attention for article published in Diabetes, Obesity & Metabolism, October 2018
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Title
Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo‐controlled cross‐over study
Published in
Diabetes, Obesity & Metabolism, October 2018
DOI 10.1111/dom.13539
Pubmed ID
Authors

Moe Thuzar, Weikiat Phillip Law, Goce Dimeski, Michael Stowasser, Ken K. Y. Ho

Abstract

To investigate whether mineralocorticoid (MC) antagonism enhances brown adipose tissue (BAT) function in humans. In a randomized double-blind cross-over design, 10 healthy adults (2 men, 8 women) underwent two weeks of spironolactone (100mg/day) and placebo treatments with an intervening 2-week wash-out. BAT function was assessed in response to cooling and to a mixed meal. Metabolic activity was measured by fluoro-deoxyglucose (FDG) uptake (maximal standardized uptake value, SUVmax ) using PET-CT, thermogenic activity by measuring skin temperatures overlying supraclavicular (SCL) BAT depots using infrared thermography, and postprandial metabolism by measuring energy production rate (EPR) and lipid synthesis using indirect calorimetry. During cooling, BAT metabolic activity (SUV 6.30±2.16 vs 3.98±1.34; P<0.05) and volume (54.9±22.8 vs 21.6±11.8 cm3 ; P<0.05) were significantly higher, and mean SCL temperature fell by a smaller degree (-0.3±0.2 vs -0.9±0.20 C; P=0.05) with spironolactone treatment. A mixed meal increased SCL temperature and EPR. The postprandial rise in SCL temperature (+0.4±0.1 vs +0.1±0.10 C; P<0.05) but not EPR was greater during spironolactone treatment. Postprandial lipid synthesis occurred in three subjects during placebo but none during spironolactone treatment (P=0.06). MC antagonism enhanced human BAT function in response to cooling and to a meal during which lipid synthesis was suppressed. As postprandial EPR comprises energy dissipated as heat and energy required to store nutrients, the reduction in lipid synthesis during MC antagonism is a likely consequence of concurrent stimulation of BAT thermogenesis. The shift of energy usage from storage to heat dissipation indicates that MC antagonists may have therapeutic benefit for obesity. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 21%
Researcher 5 9%
Student > Ph. D. Student 5 9%
Student > Postgraduate 3 5%
Professor 3 5%
Other 8 14%
Unknown 22 38%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Nursing and Health Professions 5 9%
Sports and Recreations 5 9%
Biochemistry, Genetics and Molecular Biology 3 5%
Psychology 2 3%
Other 10 17%
Unknown 22 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2018.
All research outputs
#16,728,456
of 25,385,509 outputs
Outputs from Diabetes, Obesity & Metabolism
#2,633
of 3,582 outputs
Outputs of similar age
#218,215
of 358,650 outputs
Outputs of similar age from Diabetes, Obesity & Metabolism
#55
of 80 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,582 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,650 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.