| Title |
Mortality in Patients With Out-of-Hospital Cardiac Arrest Undergoing a Standardized Protocol Including Therapeutic Hypothermia and Routine Coronary Angiography Experience From the HACORE Registry
|
|---|---|
| Published in |
JACC: Cardiovascular Interventions, September 2018
|
| DOI | 10.1016/j.jcin.2018.06.022 |
| Pubmed ID | |
| Authors |
Muharrem Akin, Jan-Thorben Sieweke, Florian Zauner, Vera Garcheva, Jörn Tongers, L. Christian Napp, Lars Friedrich, Jens Treptau, Max-Udo Bahntje, Ulrike Flierl, Daniel G. Sedding, Johann Bauersachs, Andreas Schäfer |
| Abstract |
This study sought to analyze the impact of mandatory therapeutic hypothermia and cardiac catheterization in the absence of overt noncardiac cause of arrest as part of the Hannover Cardiac Resuscitation Algorithm before intensive care admission. Despite advanced therapies, out-of-hospital cardiac arrest (OHCA) is still associated with high mortality rates. Recently, the TTM (Target Temperature Management 33°C Versus 36°C After Out-of-Hospital Cardiac Arrest)-trial caused severe uncertainty about the efficacy of and need for therapeutic hypothermia. Furthermore, the role of early coronary angiography in OHCA survivors without ST-segment elevation remains undetermined. In the HACORE (HAnnover Cooling REgistry) we investigated 233 consecutive patients (median age 64 [interquartile range: 53 to 74] years) with OHCA admitted to our institution between January 2011 and December 2015 who were treated according to the algorithm. A total of 73% had ventricular fibrillation as primary rhythm. Return of spontaneous circulation was achieved after 20 (interquartile range: 10 to 30) min. Immediate percutaneous coronary angiography was performed in 96% and coronary angioplasty in 59% of all cases. ST-segment elevation was present in 47%. Critical coronary stenosis requiring percutaneous coronary intervention was present in 67% of patients with and 52% of patients without ST-segment elevation. Overall 30-day intrahospital mortality in this real-world registry was 37%. Patients in our local registry who matched the inclusion/exclusion criteria of the TTM-trial (n = 145) had a markedly lower 30-day mortality (27%) compared with the published trial (44%). Standardized treatment of patients with OHCA following a strict protocol incorporating computed tomography, cardiac catheterization and revascularization, liberal use of active hemodynamic support in presence of shock, and mandatory therapeutic hypothermia results in mortality rates lower than previously reported. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 6 | 19% |
| United States | 6 | 19% |
| United Kingdom | 3 | 9% |
| Netherlands | 2 | 6% |
| Portugal | 1 | 3% |
| Italy | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| India | 1 | 3% |
| Germany | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 69% |
| Scientists | 4 | 13% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Science communicators (journalists, bloggers, editors) | 3 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 6 | 11% |
| Student > Bachelor | 6 | 11% |
| Student > Master | 4 | 7% |
| Other | 4 | 7% |
| Professor > Associate Professor | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 23 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 43% |
| Nursing and Health Professions | 5 | 9% |
| Engineering | 2 | 4% |
| Social Sciences | 1 | 2% |
| Neuroscience | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 22 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2018.
All research outputs
#1,187,804
of 25,385,509 outputs
Outputs from JACC: Cardiovascular Interventions
#481
of 4,032 outputs
Outputs of similar age
#25,014
of 345,739 outputs
Outputs of similar age from JACC: Cardiovascular Interventions
#10
of 86 outputs
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So far Altmetric has tracked 4,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done well, scoring higher than 88% of its peers.
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