| Title |
Transplantation of mesenchymal stem cells improves type 1 diabetes mellitus
|
|---|---|
| Published in |
Cell and Tissue Research, December 2015
|
| DOI | 10.1007/s00441-015-2330-5 |
| Pubmed ID | |
| Authors |
Lisha Li, Furong Li, Feng Gao, Yali Yang, Yuanyuan Liu, Pingping Guo, Yulin Li |
| Abstract |
Bone-marrow-derived stem cells can regenerate pancreatic tissue in a model of type 1 diabetes mellitus. Mesenchymal stem cells (MSCs) form the main part of bone marrow. We show that the intrapancreatic transplantation of MSCs elevates serum insulin and C-peptide, while decreasing blood glucose. MSCs engrafted into the damaged rat pancreas become distributed into the blood vessels, acini, ducts, and islets. Renascent islets, islet-like clusters, and a small number of MSCs expressing insulin protein have been observed in the pancreas of diabetic rats. Intrapancreatic transplantation of MSCs triggers a series of molecular and cellular events, including differentiation towards the pancreas directly and the provision of a niche to start endogenous pancreatic regeneration, which ameliorates hypoinsulinemia and hyperglycemia caused by streptozotocin. These data establish the many roles of MSCs in the restoration of the function of an injured organ. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 48 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 20% |
| Student > Master | 8 | 16% |
| Researcher | 7 | 14% |
| Student > Ph. D. Student | 6 | 12% |
| Other | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 24% |
| Agricultural and Biological Sciences | 10 | 20% |
| Medicine and Dentistry | 7 | 14% |
| Veterinary Science and Veterinary Medicine | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2015.
All research outputs
#18,563,902
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#1,645
of 2,279 outputs
Outputs of similar age
#270,076
of 393,839 outputs
Outputs of similar age from Cell and Tissue Research
#13
of 23 outputs
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So far Altmetric has tracked 2,279 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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