| Title |
Thick ascending limb: the Na+:K+:2Cl− co-transporter, NKCC2, and the calcium-sensing receptor, CaSR
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, November 2008
|
| DOI | 10.1007/s00424-008-0607-1 |
| Pubmed ID | |
| Authors |
Gerardo Gamba, Peter A. Friedman |
| Abstract |
The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na(+):K(+):2Cl(-) co-transporter, the K(+) channel, and basolateral Cl(-) channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca(2+) and Mg(2+) absorption. Calcium-sensing receptor activation inhibits cellular Ca(2+) absorption induced by parathyroid hormone, as well as passive paracellular Ca(2+) transport. The present review discusses these functions and their genetic and molecular regulation. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 75% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| United States | 1 | <1% |
| Greece | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 102 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 18% |
| Student > Ph. D. Student | 17 | 16% |
| Researcher | 10 | 9% |
| Student > Master | 9 | 8% |
| Student > Doctoral Student | 9 | 8% |
| Other | 19 | 18% |
| Unknown | 23 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 25% |
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Agricultural and Biological Sciences | 19 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Veterinary Science and Veterinary Medicine | 2 | 2% |
| Other | 8 | 8% |
| Unknown | 27 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2021.
All research outputs
#5,960,451
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#334
of 1,973 outputs
Outputs of similar age
#27,233
of 94,622 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#3
of 8 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,622 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.