| Title |
Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization
|
|---|---|
| Published in |
Journal of Assisted Reproduction and Genetics, September 2018
|
| DOI | 10.1007/s10815-018-1318-y |
| Pubmed ID | |
| Authors |
I. Lindgren, H. Nenonen, E. Henic, L. Bungum, A. Prahl, M. Bungum, I. Leijonhufvud, I. Huhtaniemi, C. Yding Andersen, Y. Lundberg Giwercman |
| Abstract |
The objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF). A total of 665 women were consecutively enrolled for IVF during the period 2007-2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m2, non-smoking, regular menstruation cycle of 21-35 days, and bilateral ovaries. A blood sample was drawn for endocrine hormonal analysis and for DNA extraction with subsequent genotyping of the FSHR N680S and LHCGR N312S polymorphisms. Statistical analyses were done on all completed IVF cycles. Women homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049). Gonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 18% |
| Student > Ph. D. Student | 4 | 12% |
| Lecturer | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Researcher | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 13 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 27% |
| Nursing and Health Professions | 2 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Computer Science | 1 | 3% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 18 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#19,611,252
of 24,119,703 outputs
Outputs from Journal of Assisted Reproduction and Genetics
#1,199
of 1,697 outputs
Outputs of similar age
#266,796
of 345,480 outputs
Outputs of similar age from Journal of Assisted Reproduction and Genetics
#26
of 36 outputs
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