| Title |
Predictors and Clinical Impact of Late Ventricular Arrhythmias in Patients With Continuous-Flow Left Ventricular Assist Devices
|
|---|---|
| Published in |
JACC: Clinical Electrophysiology, July 2018
|
| DOI | 10.1016/j.jacep.2018.05.006 |
| Pubmed ID | |
| Authors |
Vincent Galand, Erwan Flécher, Vincent Auffret, Stéphane Boulé, André Vincentelli, Camille Dambrin, Pierre Mondoly, Frédéric Sacher, Karine Nubret, Michel Kindo, Thomas Cardi, Philippe Gaudard, Philippe Rouvière, Magali Michel, Jean-Baptiste Gourraud, Pascal Defaye, Olivier Chavanon, Constance Verdonk, Walid Ghodbane, Edeline Pelcé, Vlad Gariboldi, Matteo Pozzi, Jean-François Obadia, Pierre-Yves Litzler, Frédéric Anselme, Gerard Babatasi, Annette Belin, Fabien Garnier, Marie Bielefeld, David Hamon, Costin Radu, Bertrand Pierre, Thierry Bourguignon, Romain Eschalier, Nicolas D’Ostrevy, Marie-Cécile Bories, Eloi Marijon, Fabrice Vanhuyse, Hugues Blangy, Jean-Philippe Verhoye, Christophe Leclercq, Raphaël P. Martins, ASSIST-ICD Investigators |
| Abstract |
This study aimed to evaluate the incidence, clinical impact, and predictors of late ventricular arrhythmias (VAs) in left ventricular assist device (LVAD) recipients aiming to clarify implantable cardioverter-defibrillator (ICD) indications. The arrhythmic risk and need for ICD in patients implanted with an LVAD are not very well known. This observational study was conducted in 19 centers between 2006 and 2016. Late VAs were defined as sustained ventricular tachycardia or fibrillation occurring >30 days post-LVAD implantation, without acute reversible cause and requiring appropriate ICD therapy, external electrical shock, or medical therapy. Among 659 LVAD recipients, 494 (median 58.9 years of age; mean left ventricular ejection fraction 20.7 ± 7.4%; 73.1% HeartMate II, 18.6% HeartWare, 8.3% Jarvik 2000) were discharged alive from hospital and included in the final analysis. Late VAs occurred in 133 (26.9%) patients. Multivariable analysis identified 6 independent predictors of late VAs: VAs before LVAD implantation, atrial fibrillation before LVAD implantation, idiopathic etiology of the cardiomyopathy, heart failure duration >12 months, early VAs (<30 days post-LVAD), and no angiotensin-converting enzyme inhibitors during follow-up. The "VT-LVAD score" was created, identifying 4 risk groups: low (score 0 to 1), intermediate (score 2 to 4), high (score 5 to 6), and very high (score 7 to 10). The rates of VAs at 1 year were 0.0%, 8.0%, 31.0% and 55.0%, respectively. Late VAs are common after LVAD implantation. The VT-LVAD score may help to identify patients at risk of late VAs and guide ICD indications in previously nonimplanted patients. (Determination of Risk Factors of Ventricular Arrhythmias [VAs] after implantation of continuous flow left ventricular assist device with continuous flow left ventricular assist device [CF-LVAD] [ASSIST-ICD]; NCT02873169). |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 50% |
| Spain | 2 | 7% |
| Brazil | 1 | 3% |
| Cyprus | 1 | 3% |
| India | 1 | 3% |
| Australia | 1 | 3% |
| Singapore | 1 | 3% |
| Argentina | 1 | 3% |
| France | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 6 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 53% |
| Scientists | 8 | 27% |
| Practitioners (doctors, other healthcare professionals) | 5 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 13% |
| Student > Bachelor | 5 | 9% |
| Student > Doctoral Student | 5 | 9% |
| Other | 4 | 7% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 9 | 16% |
| Unknown | 22 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 36% |
| Nursing and Health Professions | 2 | 4% |
| Neuroscience | 2 | 4% |
| Economics, Econometrics and Finance | 1 | 2% |
| Psychology | 1 | 2% |
| Other | 5 | 9% |
| Unknown | 25 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2019.
All research outputs
#1,434,620
of 25,461,852 outputs
Outputs from JACC: Clinical Electrophysiology
#308
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Outputs of similar age
#29,703
of 341,491 outputs
Outputs of similar age from JACC: Clinical Electrophysiology
#10
of 51 outputs
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