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Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism

Overview of attention for article published in Journal of Trauma and Acute Care Surgery, The, January 2019
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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1 blog
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29 X users
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1 Facebook page

Citations

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140 Dimensions

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146 Mendeley
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Title
Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism
Published in
Journal of Trauma and Acute Care Surgery, The, January 2019
DOI 10.1097/ta.0000000000002061
Pubmed ID
Authors

Sara P. Myers, Matthew E. Kutcher, Matthew R. Rosengart, Jason L. Sperry, Andrew B. Peitzman, Joshua B. Brown, Matthew D. Neal

Abstract

Tranexamic acid (TXA) is used as a hemostatic adjunct for hemorrhage control in the injured patient and reduces early preventable death. But the risk of venous thromboembolism (VTE) has been incompletely explored. Previous studies investigating the effect of TXA on VTE vary in their findings. We performed a propensity matched analysis to investigate the association between TXA and VTE following trauma, hypothesizing that TXA is an independent risk factor for VTE. This retrospective study queried trauma patients presenting to a single level I trauma center from 2012 to 2016. Our primary outcome was composite pulmonary embolism or deep vein thrombosis. Mortality, transfusion, ICU and hospital lengths of stay (LOS) were secondary outcomes. Propensity matched mixed effects multivariate logistic regression was used to determine adjusted odds ratio (aOR) and 95% confidence intervals of TXA on outcomes of interest, adjusting for prespecified confounders. Competing risks regression assessed subdistribution hazard ratio (SHR) of VTE after accounting for mortality. Out of 21,931 patients, 189 pairs were well matched across propensity score variables (standardized differences <0.2). Median ISS was 19 (IQR 12, 27) and 14 (IQR 8, 22) in TXA and non-TXA groups, respectively (p=0.19). TXA was associated with more than 3-fold increase in the odds of VTE (aOR 3.3; 95%CI 1.3-9.1, p=0.02). TXA was not significantly associated with survival (aOR 0.86; 95%CI 0.23-3.25, p=0.83). Risk of VTE remained elevated in the TXA cohort despite accounting for mortality (SHR 2.42; 95% CI 1.11-5.29, p=0.03). TXA may be an independent risk factor for VTE. Future investigation is needed to identify which patients benefit most from TXA, especially given risks of this intervention, to allow a more individualized treatment approach that maximizes benefits and mitigates potential harms. Level III; Therapeutic.

X Demographics

X Demographics

The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 146 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 13%
Researcher 16 11%
Student > Master 14 10%
Other 13 9%
Student > Ph. D. Student 12 8%
Other 30 21%
Unknown 42 29%
Readers by discipline Count As %
Medicine and Dentistry 72 49%
Nursing and Health Professions 8 5%
Unspecified 6 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Biochemistry, Genetics and Molecular Biology 1 <1%
Other 5 3%
Unknown 51 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2022.
All research outputs
#1,379,951
of 25,385,509 outputs
Outputs from Journal of Trauma and Acute Care Surgery, The
#382
of 7,802 outputs
Outputs of similar age
#31,755
of 446,394 outputs
Outputs of similar age from Journal of Trauma and Acute Care Surgery, The
#6
of 84 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,802 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,394 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.