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Topical Mannitol Reduces Capsaicin‐Induced Pain: Results of a Pilot‐Level, Double‐Blind, Randomized Controlled Trial

Overview of attention for article published in PM&R, May 2015
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Title
Topical Mannitol Reduces Capsaicin‐Induced Pain: Results of a Pilot‐Level, Double‐Blind, Randomized Controlled Trial
Published in
PM&R, May 2015
DOI 10.1016/j.pmrj.2015.05.002
Pubmed ID
Authors

Helene Bertrand, Marylene Kyriazis, K. Dean Reeves, John Lyftogt, David Rabago

Abstract

Capsaicin specifically activates, and then gradually exhausts, the transient receptor potential vanilloid type 1 (TRPV-1) receptor, a key receptor in neuropathic pain. Activation of the TRPV-1 receptor is accompanied by burning pain. A natural substance or medication that can reduce the burning pain resultant from capsaicin application may have therapeutic potential in neuropathic pain. To assess the pain relieving effects of a mannitol-containing cream in a capsaicin-based pain model. Randomized, placebo-controlled, double-blind clinical trial. Outpatient pain clinic. Twenty five adults with pain-free lips. Capsaicin .075% cream was applied to both halves of each participant's upper lip, inducing pain via stimulation of the transient receptor potential vanilloid one (TRPV1, capsaicin) receptor, then removed after five minutes, or when participants reported a burning pain of 8/10, whichever came first. A cream containing mannitol and the same cream without mannitol (control) were then immediately applied, one on each side of the lip, in an allocation-masked manner. Participants self-recorded a numerical rating scale (NRS, 0-10) pain score for each side of the lip per minute for 10 minutes. A t-test was performed to evaluate the pain-score change from baseline between each side of the lip at each recording. Area under the curve (AUC) analysis was used to determine the overall difference between groups. Participants reached a capsaicin-induced pain level of 7.8±1.0 points in 3.3±1.6 minutes that was equal on both sides of the lip. Both groups reported progressive diminution of pain over the 10-minute study period. However, participants reported significantly reduced pain scores on the mannitol cream half-lip compared to control at 3 through 10 minutes (p<.05), and in AUC analysis (p<.001). Mannitol cream reduced self-reported pain scores in a capsaicin pain model more rapidly than a control cream, potentially via a TRPV1 receptor effect.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 14%
Other 7 11%
Researcher 5 8%
Student > Postgraduate 5 8%
Student > Doctoral Student 5 8%
Other 16 24%
Unknown 19 29%
Readers by discipline Count As %
Medicine and Dentistry 21 32%
Nursing and Health Professions 5 8%
Neuroscience 4 6%
Agricultural and Biological Sciences 3 5%
Chemistry 3 5%
Other 14 21%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2015.
All research outputs
#19,869,877
of 24,417,958 outputs
Outputs from PM&R
#1,478
of 1,717 outputs
Outputs of similar age
#198,036
of 268,790 outputs
Outputs of similar age from PM&R
#41
of 56 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,717 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.