| Title |
Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, December 2015
|
| DOI | 10.1007/s10803-015-2672-6 |
| Pubmed ID | |
| Authors |
E. C. Azmitia, Z. T. Saccomano, M. F. Alzoobaee, M. Boldrini, P. M. Whitaker-Azmitia |
| Abstract |
In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in cells of the vascular system, indicating blood vessels plasticity. Evidence of angiogenesis was seen throughout superior temporal cortex (primary auditory cortex), fusiform cortex (face recognition center), pons/midbrain and cerebellum in postmortem brains from ASD patients but not control brains. We found significant increases in both nestin and CD34, which are markers of angiogenesis localized to pericyte cells and endothelial cells, respectively. This labeling profile is indicative of splitting (intussusceptive), rather than sprouting, angiogenesis indicating the blood vessels are in constant flux rather than continually expanding. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 18% |
| United States | 1 | 9% |
| Saudi Arabia | 1 | 9% |
| Japan | 1 | 9% |
| Unknown | 6 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Practitioners (doctors, other healthcare professionals) | 3 | 27% |
| Scientists | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Unknown | 107 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 16% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 12 | 11% |
| Student > Ph. D. Student | 10 | 9% |
| Student > Doctoral Student | 9 | 8% |
| Other | 23 | 21% |
| Unknown | 26 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 18% |
| Medicine and Dentistry | 14 | 13% |
| Psychology | 13 | 12% |
| Agricultural and Biological Sciences | 8 | 7% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Other | 14 | 13% |
| Unknown | 34 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 91. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2020.
All research outputs
#473,725
of 25,769,258 outputs
Outputs from Journal of Autism and Developmental Disorders
#130
of 5,454 outputs
Outputs of similar age
#7,763
of 398,759 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#1
of 73 outputs
Altmetric has tracked 25,769,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,454 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.