Title |
TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition
|
---|---|
Published in |
Immunogenetics, December 2011
|
DOI | 10.1007/s00251-011-0590-0 |
Pubmed ID | |
Authors |
L. J. D’Orsogna, D. L. Roelen, I. I. N. Doxiadis, F. H. J. Claas |
Abstract |
Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA molecules and that this allorecognition exhibits exquisite peptide and HLA specificity and is dependent on both public and private specificities of the T cell receptor. In this review we highlight new insights gained into the immunogenetics of allorecognition, with particular emphasis on how viral infection and vaccination may specifically activate allo-HLA reactive T cells. We also briefly discuss the potential for virus-specific T cell infusions to produce GvHD. The progress made in understanding the molecular basis of allograft rejection will hopefully be translated into improved allograft function and/or survival, and eventually tolerance induction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
United States | 1 | 1% |
Czechia | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 93 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 23% |
Researcher | 21 | 22% |
Other | 11 | 11% |
Student > Master | 11 | 11% |
Student > Bachelor | 6 | 6% |
Other | 14 | 14% |
Unknown | 12 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 26% |
Agricultural and Biological Sciences | 21 | 22% |
Immunology and Microbiology | 17 | 18% |
Biochemistry, Genetics and Molecular Biology | 11 | 11% |
Neuroscience | 2 | 2% |
Other | 5 | 5% |
Unknown | 16 | 16% |