| Title |
Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex
|
|---|---|
| Published in |
Experimental Brain Research, December 2011
|
| DOI | 10.1007/s00221-011-2968-5 |
| Pubmed ID | |
| Authors |
Alkomiet Hasan, Masashi Hamada, Michael A. Nitsche, Diane Ruge, Joseph M. Galea, Thomas Wobrock, John C. Rothwell |
| Abstract |
Animal studies using polarising currents have shown that induction of synaptic long-term potentiation (LTP) and long-term depression (LTD) by bursts of patterned stimulation is affected by the membrane potential of the postsynaptic neurone. The aim of the present experiments was to test whether it is possible to observe similar phenomena in humans with the aim of improving present protocols of inducing synaptic plasticity for therapeutic purposes. We tested whether the LTP/LTD-like after effects of transcranial theta-burst stimulation (TBS) of human motor cortex, an analogue of patterned electrical stimulation in animals, were affected by simultaneous transcranial direct-current stimulation (tDCS), a non-invasive method of polarising cortical neurones in humans. Nine healthy volunteers were investigated in a single-blind, balanced cross-over study; continuous TBS (cTBS) was used to introduce LTD-like after effects, whereas intermittent TBS (iTBS) produced LTP-like effects. Each pattern was coupled with concurrent application of tDCS (<200 s, anodal, cathodal, sham). Cathodal tDCS increased the response to iTBS and abolished the effects of cTBS. Anodal tDCS changed the effects of cTBS towards facilitation, but had no impact on iTBS. Cortical motor thresholds and intracortical inhibitory/facilitatory networks were not altered by any of the stimulation protocols. We conclude that the after effects of TBS can be modulated by concurrent tDCS. We hypothesise that tDCS changes the membrane potential of the apical dendrites of cortical pyramidal neurones and that this changes the response to patterned synaptic input evoked by TBS. The data show that it may be possible to enhance LTP-like plasticity after TBS in the human cortex. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Israel | 1 | <1% |
| Canada | 1 | <1% |
| Japan | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 93 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 24% |
| Researcher | 20 | 20% |
| Student > Master | 11 | 11% |
| Professor > Associate Professor | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 20% |
| Medicine and Dentistry | 18 | 18% |
| Psychology | 14 | 14% |
| Agricultural and Biological Sciences | 7 | 7% |
| Engineering | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 28 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2020.
All research outputs
#7,229,289
of 23,577,654 outputs
Outputs from Experimental Brain Research
#813
of 3,281 outputs
Outputs of similar age
#64,662
of 244,588 outputs
Outputs of similar age from Experimental Brain Research
#7
of 31 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,281 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 74% of its peers.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.