| Title |
Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, December 2015
|
| DOI | 10.1007/s00406-015-0665-2 |
| Pubmed ID | |
| Authors |
Fábio B. Mury, Weber C. da Silva, Nádia R. Barbosa, Camila T. Mendes, Juliana S. Bonini, Jorge Eduardo Souza Sarkis, Martin Cammarota, Ivan Izquierdo, Wagner F. Gattaz, Emmanuel Dias-Neto |
| Abstract |
Phospholipase A2 (Pla2) is required for memory retrieval, and its inhibition in the hippocampus has been reported to impair memory acquisition in rats. Moreover, cognitive decline and memory deficits showed to be reduced in animal models after lithium treatment, prompting us to evaluate possible links between Pla2, lithium and memory. Here, we evaluated the possible modulation of Pla2 activity by a long-term treatment of rats with low doses of lithium and its impact in memory. Wistar rats were trained for the inhibitory avoidance task, treated with lithium for 100 days and tested for perdurability of long-term memory. Hippocampal samples were used for quantifying the expression of 19 brain-expressed Pla2 genes and for evaluating the enzymatic activity of Pla2 using group-specific radio-enzymatic assays. Our data pointed to a significant perdurability of long-term memory, which correlated with increased transcriptional and enzymatic activities of certain members of the Pla2 family (iPla2 and sPla2) after the chronic lithium treatment. Our data suggest new possible targets of lithium, add more information on its pharmacological activity and reinforce the possible use of low doses of lithium for the treatment of neurodegenerative conditions such as the Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 23% |
| Student > Bachelor | 8 | 19% |
| Student > Doctoral Student | 3 | 7% |
| Professor | 2 | 5% |
| Researcher | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 16% |
| Psychology | 6 | 14% |
| Medicine and Dentistry | 6 | 14% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#4,344,028
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#241
of 1,243 outputs
Outputs of similar age
#70,342
of 393,263 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#2
of 17 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.