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SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

Overview of attention for article published in PLoS Pathogens, December 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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1 X user
wikipedia
2 Wikipedia pages

Citations

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221 Dimensions

Readers on

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137 Mendeley
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1 CiteULike
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Title
SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection
Published in
PLoS Pathogens, December 2011
DOI 10.1371/journal.ppat.1002425
Pubmed ID
Authors

André Berger, Andreas F. R. Sommer, Jenny Zwarg, Matthias Hamdorf, Karin Welzel, Nicole Esly, Sylvia Panitz, Andreas Reuter, Irene Ramos, Asavari Jatiani, Lubbertus C. F. Mulder, Ana Fernandez-Sesma, Frank Rutsch, Viviana Simon, Renate König, Egbert Flory

Abstract

Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates infection of these cells by counteracting the host restriction factor SAMHD1. Here, we independently confirmed that Vpx interacts with SAMHD1 and targets it for ubiquitin-mediated degradation. We found that Vpx-mediated SAMHD1 degradation rendered primary monocytes highly susceptible to HIV-1 infection; Vpx with a T17A mutation, defective for SAMHD1 binding and degradation, did not show this activity. Several single nucleotide polymorphisms in the SAMHD1 gene have been associated with Aicardi-Goutières syndrome (AGS), a very rare and severe autoimmune disease. Primary peripheral blood mononuclear cells (PBMC) from AGS patients homozygous for a nonsense mutation in SAMHD1 (R164X) lacked endogenous SAMHD1 expression and support HIV-1 replication in the absence of exogenous activation. Our results indicate that within PBMC from AGS patients, CD14+ cells were the subpopulation susceptible to HIV-1 infection, whereas cells from healthy donors did not support infection. The monocytic lineage of the infected SAMHD1 -/- cells, in conjunction with mostly undetectable levels of cytokines, chemokines and type I interferon measured prior to infection, indicate that aberrant cellular activation is not the cause for the observed phenotype. Taken together, we propose that SAMHD1 protects primary CD14+ monocytes from HIV-1 infection confirming SAMHD1 as a potent lentiviral restriction factor.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 1 <1%
Switzerland 1 <1%
Unknown 133 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 28%
Researcher 26 19%
Student > Master 17 12%
Student > Bachelor 13 9%
Student > Doctoral Student 7 5%
Other 19 14%
Unknown 17 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 57 42%
Biochemistry, Genetics and Molecular Biology 26 19%
Immunology and Microbiology 15 11%
Medicine and Dentistry 14 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 <1%
Other 5 4%
Unknown 19 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2015.
All research outputs
#7,960,512
of 25,374,917 outputs
Outputs from PLoS Pathogens
#5,855
of 9,467 outputs
Outputs of similar age
#66,071
of 246,971 outputs
Outputs of similar age from PLoS Pathogens
#65
of 149 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 9,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,971 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.