| Title |
The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer—a randomized-controlled trial
|
|---|---|
| Published in |
Gastric Cancer, September 2018
|
| DOI | 10.1007/s10120-018-0879-x |
| Pubmed ID | |
| Authors |
Lapo Bencini, Alberto Marchet, Sergio Alfieri, Fausto Rosa, Giuseppe Verlato, Daniele Marrelli, Franco Roviello, Fabio Pacelli, Luigi Cristadoro, Antonio Taddei, Marco Farsi, Italian Research Group for Gastric Cancer (GIRCG) |
| Abstract |
The incidence of cholelithiasis has been shown to be higher for patients after gastrectomy than for the general population, due to vagal branch damage and gastrointestinal reconstruction. The aim of this trial was to evaluate the need for routine concomitant prophylactic cholecystectomy (PC) during gastrectomy for cancer. A multicenter, randomized, controlled trial was conducted between November 2008 and March 2017. Of the total 130 included patients, 65 underwent PC and 65 underwent standard gastric surgery only for curable cancers. The primary endpoint was cholelithiasis-free survival after gastrectomy for gastric adenocarcinoma. Cholelithiasis was detected by ultrasound exam. After a median follow-up of 62 months, eight patients (12.3%) in the control group developed biliary abnormalities (four cases of gallbladder calculi and four cases of biliary sludge), with only three (4.6%) being clinically relevant (two cholecystectomies needed, one acute pancreatitis). One patient in the PC group had asymptomatic biliary dilatation during sonography after surgery. The cholelithiasis-free survival did not show statistical significance between the two groups (P = 0.267). The number needed to treat with PC to avoid reoperation for cholelithiasis was 1:32.5. Concomitant PC during gastric surgery for malignancies, although reducing the absolute number of biliary abnormalities, has no significant impact on the natural course of patients. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 14% |
| Student > Master | 7 | 12% |
| Researcher | 6 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Librarian | 3 | 5% |
| Other | 11 | 19% |
| Unknown | 18 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 39% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Computer Science | 2 | 4% |
| Psychology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 23 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2020.
All research outputs
#13,900,658
of 23,577,761 outputs
Outputs from Gastric Cancer
#254
of 609 outputs
Outputs of similar age
#174,754
of 341,931 outputs
Outputs of similar age from Gastric Cancer
#7
of 14 outputs
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