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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcriptional elongation requires DNA break-induced signalling
|
|---|---|
| Published in |
Nature Communications, December 2015
|
| DOI | 10.1038/ncomms10191 |
| Pubmed ID | |
| Authors |
Heeyoun Bunch, Brian P. Lawney, Yu-Fen Lin, Aroumougame Asaithamby, Ayesha Murshid, Yaoyu E. Wang, Benjamin P. C. Chen, Stuart K. Calderwood |
| Abstract |
We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK. Here we report a significant role for DNA breaks and DDR signalling in the mechanisms of transcriptional elongation in stimulus-inducible genes in humans. Our data show the enrichment of TRIM28 and γH2AX on serum-induced genes and the important function of DNA-PK for Pol II pause release and transcriptional activation-coupled DDR signalling on these genes. γH2AX accumulation decreases when P-TEFb is inhibited, confirming that DDR signalling results from transcriptional elongation. In addition, transcriptional elongation-coupled DDR signalling involves topoisomerase II because inhibiting this enzyme interferes with Pol II pause release and γH2AX accumulation. Our findings propose that DDR signalling is required for effective Pol II pause release and transcriptional elongation through a novel mechanism involving TRIM28, DNA-PK and topoisomerase II. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| France | 1 | 17% |
| Korea, Republic of | 1 | 17% |
| Estonia | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 294 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 287 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 76 | 26% |
| Researcher | 51 | 17% |
| Student > Bachelor | 37 | 13% |
| Student > Master | 28 | 10% |
| Professor | 13 | 4% |
| Other | 42 | 14% |
| Unknown | 47 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 111 | 38% |
| Agricultural and Biological Sciences | 69 | 23% |
| Medicine and Dentistry | 26 | 9% |
| Neuroscience | 8 | 3% |
| Immunology and Microbiology | 7 | 2% |
| Other | 21 | 7% |
| Unknown | 52 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2022.
All research outputs
#2,182,032
of 23,905,714 outputs
Outputs from Nature Communications
#25,565
of 49,996 outputs
Outputs of similar age
#37,618
of 396,435 outputs
Outputs of similar age from Nature Communications
#331
of 690 outputs
Altmetric has tracked 23,905,714 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,996 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,435 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 690 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.