| Title |
G protein-coupled receptors as new therapeutic targets for type 2 diabetes
|
|---|---|
| Published in |
Diabetologia, December 2015
|
| DOI | 10.1007/s00125-015-3825-z |
| Pubmed ID | |
| Authors |
Frank Reimann, Fiona M. Gribble |
| Abstract |
G protein-coupled receptors (GPCRs) in the gut-brain-pancreatic axis are key players in the postprandial control of metabolism and food intake. A number of intestinally located receptors have been implicated in the chemo-detection of ingested nutrients, and in the pancreatic islets and nervous system GPCRs play essential roles in the detection of many hormones and neurotransmitters. Because of the diversity, cell-specific expression and 'druggability' of the GPCR superfamily, these receptors are popular targets for therapeutic development. This review will outline current and potential future approaches to develop GPCR agonists for the treatment of type 2 diabetes. This review summarises a presentation given at the 'Novel approaches to treating type 2 diabetes' symposium at the 2015 annual meeting of the EASD. It is accompanied by a commentary by the Session Chair, Michael Nauck (DOI: 10.1007/s00125-015-3823-1 ). |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 23% |
| United Kingdom | 2 | 15% |
| Canada | 1 | 8% |
| Jamaica | 1 | 8% |
| Mexico | 1 | 8% |
| Belgium | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 62% |
| Scientists | 5 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Sweden | 1 | <1% |
| Argentina | 1 | <1% |
| Nigeria | 1 | <1% |
| Russia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 157 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 23% |
| Student > Master | 33 | 20% |
| Student > Bachelor | 20 | 12% |
| Researcher | 17 | 10% |
| Other | 11 | 7% |
| Other | 19 | 12% |
| Unknown | 27 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 21% |
| Agricultural and Biological Sciences | 31 | 19% |
| Medicine and Dentistry | 25 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 15% |
| Chemistry | 7 | 4% |
| Other | 16 | 10% |
| Unknown | 28 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#3,460,055
of 25,732,188 outputs
Outputs from Diabetologia
#1,615
of 5,376 outputs
Outputs of similar age
#54,080
of 396,848 outputs
Outputs of similar age from Diabetologia
#15
of 67 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,376 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,848 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.