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MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
10 news outlets
blogs
1 blog
twitter
43 X users
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
32 Mendeley
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Title
MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype
Published in
Proceedings of the National Academy of Sciences of the United States of America, September 2018
DOI 10.1073/pnas.1722372115
Pubmed ID
Authors

Emilie Plantamura, Amiran Dzutsev, Mathias Chamaillard, Sophia Djebali, Lyvia Moudombi, Lilia Boucinha, Morgan Grau, Claire Macari, David Bauché, Oana Dumitrescu, Jean-Philippe Rasigade, Saskia Lippens, Michelina Plateroti, Elsa Kress, Annabelle Cesaro, Clovis Bondu, Ulrike Rothermel, Mathias Heikenwälder, Gerard Lina, Azzak Bentaher-Belaaouaj, Julien C. Marie, Christophe Caux, Giorgio Trinchieri, Jacqueline Marvel, Marie-Cecile Michallet

Abstract

Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report a negative regulatory role of the RIG-I-like receptor adaptor mitochondrial antiviral signaling (MAVS) on DTH by modulating gut bacterial ecology. Cohousing and fecal transplantation experiments revealed that the dysbiotic microbiota of Mavs -/- mice conferred a proallergic phenotype that is communicable to wild-type mice. DTH sensitization coincided with increased intestinal permeability and bacterial translocation within lymphoid organs that enhanced DTH severity. Collectively, we unveiled an unexpected impact of RIG-I-like signaling on the gut microbiota with consequences on allergic skin disease outcome. Primarily, these data indicate that manipulating the gut microbiota may help in the development of therapeutic strategies for the treatment of human allergic skin pathologies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 13%
Student > Bachelor 1 3%
Researcher 1 3%
Student > Postgraduate 1 3%
Unknown 25 78%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 6%
Environmental Science 1 3%
Nursing and Health Professions 1 3%
Immunology and Microbiology 1 3%
Medicine and Dentistry 1 3%
Other 0 0%
Unknown 26 81%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 100. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#413,586
of 25,080,267 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#7,422
of 102,337 outputs
Outputs of similar age
#8,878
of 346,862 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#150
of 960 outputs
Altmetric has tracked 25,080,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 102,337 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 960 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.