Title |
MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype
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Published in |
Proceedings of the National Academy of Sciences of the United States of America, September 2018
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DOI | 10.1073/pnas.1722372115 |
Pubmed ID | |
Authors |
Emilie Plantamura, Amiran Dzutsev, Mathias Chamaillard, Sophia Djebali, Lyvia Moudombi, Lilia Boucinha, Morgan Grau, Claire Macari, David Bauché, Oana Dumitrescu, Jean-Philippe Rasigade, Saskia Lippens, Michelina Plateroti, Elsa Kress, Annabelle Cesaro, Clovis Bondu, Ulrike Rothermel, Mathias Heikenwälder, Gerard Lina, Azzak Bentaher-Belaaouaj, Julien C. Marie, Christophe Caux, Giorgio Trinchieri, Jacqueline Marvel, Marie-Cecile Michallet |
Abstract |
Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report a negative regulatory role of the RIG-I-like receptor adaptor mitochondrial antiviral signaling (MAVS) on DTH by modulating gut bacterial ecology. Cohousing and fecal transplantation experiments revealed that the dysbiotic microbiota of Mavs -/- mice conferred a proallergic phenotype that is communicable to wild-type mice. DTH sensitization coincided with increased intestinal permeability and bacterial translocation within lymphoid organs that enhanced DTH severity. Collectively, we unveiled an unexpected impact of RIG-I-like signaling on the gut microbiota with consequences on allergic skin disease outcome. Primarily, these data indicate that manipulating the gut microbiota may help in the development of therapeutic strategies for the treatment of human allergic skin pathologies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 21 | 49% |
United States | 3 | 7% |
Argentina | 1 | 2% |
Canada | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 16 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 34 | 79% |
Scientists | 8 | 19% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 13% |
Student > Bachelor | 1 | 3% |
Researcher | 1 | 3% |
Student > Postgraduate | 1 | 3% |
Unknown | 25 | 78% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Environmental Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Other | 0 | 0% |
Unknown | 26 | 81% |