| Title |
Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals
|
|---|---|
| Published in |
European Journal of Nutrition, December 2015
|
| DOI | 10.1007/s00394-015-1110-z |
| Pubmed ID | |
| Authors |
Sandra Martín-Peláez, Olga Castañer, Valentini Konstantinidou, Isaac Subirana, Daniel Muñoz-Aguayo, Gemma Blanchart, Sonia Gaixas, Rafael de la Torre, Magí Farré, Guillermo T Sáez, Kristina Nyyssönen, Hans Joachim Zunft, Maria Isabel Covas, Montse Fitó |
| Abstract |
To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin-angiotensin-aldosterone system, in healthy humans. A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingested 25 mL/day of olive oils (1) high (366 mg/kg, HPC) and (2) low (2.7 mg/kg, LPC) in phenolic compounds for 3 weeks, preceded by 2-week washout periods. Determination of selected blood pressure-related gene expression in peripheral blood mononuclear cells (PBMNC) by qPCR, blood pressure and systemic biomarkers. HPC decreased systolic blood pressure compared to pre-intervention values and to LPC, and maintained diastolic blood pressure values compared to LPC. HPC decreased ACE and NR1H2 gene expressions compared with pre-intervention values, and IL8RA gene expression compared with LPC. The introduction to the diet of an extra-virgin olive oil rich in phenolic compounds modulates the expression of some of the genes related to the renin-angiotensin-aldosterone system. These changes could underlie the decrease in systolic blood pressure observed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 15% |
| Student > Master | 14 | 12% |
| Researcher | 12 | 10% |
| Student > Doctoral Student | 9 | 8% |
| Student > Ph. D. Student | 8 | 7% |
| Other | 25 | 21% |
| Unknown | 32 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 18% |
| Biochemistry, Genetics and Molecular Biology | 16 | 14% |
| Nursing and Health Professions | 15 | 13% |
| Agricultural and Biological Sciences | 12 | 10% |
| Engineering | 5 | 4% |
| Other | 10 | 9% |
| Unknown | 38 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2020.
All research outputs
#13,662,605
of 23,577,761 outputs
Outputs from European Journal of Nutrition
#1,508
of 2,453 outputs
Outputs of similar age
#186,691
of 392,213 outputs
Outputs of similar age from European Journal of Nutrition
#29
of 52 outputs
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We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.