| Title |
Effects on Cardiovascular Risk Scores and Vascular Age After Aerobic Exercise and Nutritional Intervention in Sedentary and Overweight/Obese Adults with Primary Hypertension: The EXERDIET-HTA Randomized Trial Study
|
|---|---|
| Published in |
High Blood Pressure & Cardiovascular Prevention, September 2018
|
| DOI | 10.1007/s40292-018-0281-0 |
| Pubmed ID | |
| Authors |
Ilargi Gorostegi-Anduaga, Sara Maldonado-Martín, Aitor MartinezAguirre-Betolaza, Pablo Corres, Estíbaliz Romaratezabala, Anna C. Whittaker, Silvia Francisco-Terreros, Javier Pérez-Asenjo |
| Abstract |
The EXERDIET-HTA study was a multi-arm parallel, a randomized, single-blind controlled experimental trial comparing the effects of 16 weeks of different aerobic exercise programs two days per week, and dietary intervention in a hypertensive, overweight/obese and non-physically active population. To evaluate the influence of diet and aerobic exercise program intervention on cardiovascular risk (CVR) factors and predicted CVR and vascular age (VA) profiles in overweight/obese people with primary hypertension (HTN), and to analyze the potential sex differences in the ability to predict VA and CVR via different methods. The CVR and VA determined (n = 167, 53.7 ± 7.8 years) using the Framingham Risk Score (FRS) and the new equation for the prediction of 10-year atherosclerotic cardiovascular disease (ASCVD) risk, before and after the 16-week intervention period (different aerobic exercise programs + hypocaloric diet). The sex-specific risk factors considered were age, high-density lipoprotein cholesterol (HDL-C), total cholesterol, systolic blood pressure (SBP), diabetes mellitus (DM) and smoking status. From baseline to follow-up, participants reduced (p ≤ 0.001) FRS-CVR score and VA, and SBP. Total cholesterol decreased significantly, but specifically in men (p ≤ 0.001), and antihypertensive medication (%) in women (p = 0.047). No significant differences over time were observed for HDL-C, smoking, DM overall for either sex. For ASCVD-CVR there was no overall change or for either sex. After the intervention, women had a lower CVR score than men (p ≤ 0.001), irrespective of the calculation method. The improvement in CVR factors after 16-week lifestyle changes reduced the risk of suffering a cardiovascular event in overweight/obese adults with HTN through the FRS estimation tool, but not with the ASCVD score. The risk score algorithms could underestimate CVR in women. In contrast, VA could be a useful and easier tool in the management of individuals with CVR factors. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Australia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 175 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 26 | 15% |
| Student > Master | 22 | 13% |
| Researcher | 11 | 6% |
| Student > Ph. D. Student | 9 | 5% |
| Student > Doctoral Student | 8 | 5% |
| Other | 21 | 12% |
| Unknown | 78 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 24 | 14% |
| Medicine and Dentistry | 23 | 13% |
| Sports and Recreations | 16 | 9% |
| Social Sciences | 6 | 3% |
| Biochemistry, Genetics and Molecular Biology | 4 | 2% |
| Other | 15 | 9% |
| Unknown | 87 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2018.
All research outputs
#13,662,605
of 23,577,761 outputs
Outputs from High Blood Pressure & Cardiovascular Prevention
#85
of 252 outputs
Outputs of similar age
#168,983
of 342,058 outputs
Outputs of similar age from High Blood Pressure & Cardiovascular Prevention
#1
of 8 outputs
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