Title |
Advances in silica based nanoparticles for targeted cancer therapy
|
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Published in |
Nanomedicine: Nanotechnology, Biology and Medicine, December 2015
|
DOI | 10.1016/j.nano.2015.10.018 |
Pubmed ID | |
Authors |
Yannan Yang, Chengzhong Yu |
Abstract |
Targeted delivery of anticancer drug specifically to tumour site without damaging normal tissues has been the dream of all scientists fighting against cancer for decades. Recent breakthrough on nanotechnology based medicines has provided a possible tool to solve this puzzle. Among diverse nanomaterials that are under development and extensive study, silica based nanoparticles with vast advantages have attracted great attention. In this review, we concentrate on the recent progress using silica based nanoparticles, particularly mesoporous silica nanoparticles (MSNs), for targeted drug delivery applications. Firstly, we discuss the passive targeting capability of silica based nanoparticles in relation to their physiochemical properties. Then, we focus on the recent advances of active targeting strategies involving tumour cell targeting, vascular targeting, nuclear targeting and multistage targeting, followed by an introduction to magnetic field directed targeting approach. We conclude with our personal perspectives on the remaining challenges and the possible future directions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
India | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 209 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 62 | 29% |
Student > Master | 32 | 15% |
Student > Bachelor | 29 | 14% |
Researcher | 21 | 10% |
Student > Doctoral Student | 9 | 4% |
Other | 18 | 8% |
Unknown | 43 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 44 | 21% |
Biochemistry, Genetics and Molecular Biology | 26 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 21 | 10% |
Agricultural and Biological Sciences | 19 | 9% |
Engineering | 16 | 7% |
Other | 38 | 18% |
Unknown | 50 | 23% |