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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness
|
|---|---|
| Published in |
Nature Communications, December 2015
|
| DOI | 10.1038/ncomms10186 |
| Pubmed ID | |
| Authors |
Tackhoon Kim, Suk-Jin Yang, Daehee Hwang, Jinhoi Song, Minchul Kim, Sang Kyum Kim, Keunsoo Kang, Jaebum Ahn, Daeyoup Lee, Mi-young Kim, Seyun Kim, Ja Seung Koo, Sang Seok Koh, Seon-Young Kim, Dae-Sik Lim |
| Abstract |
The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly understood. Here we show that the SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer. Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce numerous MaSC signature genes, among which the target interleukin (IL)-6 is critical for YAP-induced stemness. High SRF-YAP/TAZ expression is correlated with IL6-enriched MaSC/basal-like breast cancer (BLBC). Finally, we show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer. Collectively, our results establish the importance of SRF-YAP-IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 124 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 24% |
| Researcher | 24 | 19% |
| Student > Master | 17 | 13% |
| Student > Bachelor | 8 | 6% |
| Student > Doctoral Student | 7 | 6% |
| Other | 19 | 15% |
| Unknown | 21 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 35% |
| Agricultural and Biological Sciences | 29 | 23% |
| Medicine and Dentistry | 13 | 10% |
| Engineering | 4 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 25 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#14,830,048
of 22,835,198 outputs
Outputs from Nature Communications
#41,220
of 47,022 outputs
Outputs of similar age
#217,042
of 390,452 outputs
Outputs of similar age from Nature Communications
#574
of 688 outputs
Altmetric has tracked 22,835,198 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 47,022 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 390,452 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 688 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.