| Title |
Effects of probiotics, prebiotics or synbiotics on jawbone in obese-insulin resistant rats
|
|---|---|
| Published in |
European Journal of Nutrition, September 2018
|
| DOI | 10.1007/s00394-018-1829-4 |
| Pubmed ID | |
| Authors |
Sathima Eaimworawuthikul, Wannipa Tunapong, Titikorn Chunchai, Sakawdaurn Yasom, Keerati Wanchai, Panan Suntornsaratoon, Narattaphol Charoenphandhu, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn |
| Abstract |
Chronic high-fat diet (HFD) consumption results in gut dysbiosis, systemic inflammation, obese-insulin resistance, and osteoporosis of the jawbones. The probiotics, prebiotics or synbiotics alleviated gut dysbiosis and the metabolic disturbance in HFD-induced obesity. However, the effects on jawbone properties have not been investigated. This study aimed to investigate the effects of probiotic Lactobacillus paracasei HII01, prebiotic xylooligosaccharide (XOS), and synbiotics on the jawbone properties along with metabolic parameters, gut and systemic inflammation in HFD-fed rats. Forty-eight male Wistar rats were fed with either a HFD or normal diet for 12 weeks. Rats in each group were subdivided into four subgroups to be treated with either vehicle, probiotics, prebiotics, or synbiotics for the additional 12 weeks. Blood samples, gut, bone marrows, and jawbones were collected to determine metabolic parameters, inflammation, and bone properties. The HFD-fed rats developed obese-insulin resistance, as indicated by increased body weight, dyslipidemia and decreased insulin sensitivity. Serum lipopolysaccharide levels and interleukin-6 mRNA expression in the ileum and bone marrows were elevated. Altered bone metabolism and the impaired jawbone properties were evident as indicated by decreased bone mineral density with increased trabecular separation. Reduced ultimate load and stiffness were observed in HFD-fed rats. Treatments with probiotics, prebiotics or synbiotics in HFD-fed rats improved metabolic parameters and reduced inflammation. However, no alterations in jawbone properties were found in all treatments. The osteoporosis of the jawbone occurred in obese-insulin resistance, and treatments with probiotics, prebiotics and synbiotics were not sufficient to improve the jawbone properties. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 19% |
| Student > Bachelor | 8 | 14% |
| Student > Ph. D. Student | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 26 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Medicine and Dentistry | 7 | 12% |
| Agricultural and Biological Sciences | 4 | 7% |
| Nursing and Health Professions | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Other | 6 | 10% |
| Unknown | 27 | 46% |
Attention Score in Context
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#18,649,666
of 23,103,903 outputs
Outputs from European Journal of Nutrition
#1,978
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#260,847
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Outputs of similar age from European Journal of Nutrition
#35
of 39 outputs
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