Title |
Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis
|
---|---|
Published in |
Arthritis Research & Therapy, December 2011
|
DOI | 10.1186/ar3536 |
Pubmed ID | |
Authors |
Rhian S Thomas, Alan R Clarke, Victor C Duance, Emma J Blain |
Abstract |
Articular cartilage functions in withstanding mechanical loads and provides a lubricating surface for frictionless movement of joints. Osteoarthritis, characterised by cartilage degeneration, develops due to the progressive erosion of structural integrity and eventual loss of functional performance. Osteoarthritis is a multi-factorial disorder; two important risk factors are abnormal mechanical load and genetic predisposition. A single nucleotide polymorphism analysis demonstrated an association of hip osteoarthritis with an Arg324Gly substitution mutation in FrzB, a Wnt antagonist. The purpose of this study was two-fold: to assess whether mechanical stimulation modulates β-catenin signalling and catabolic gene expression in articular chondrocytes, and further to investigate whether there is an interplay of mechanical load and Wnt signalling in mediating a catabolic response. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 42% |
Researcher | 7 | 10% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Other | 4 | 6% |
Other | 8 | 12% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 30% |
Medicine and Dentistry | 13 | 19% |
Engineering | 10 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 5 | 7% |
Unknown | 11 | 16% |