Title |
Tissue-specific membrane effects of estrogen receptor alpha
|
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Published in |
Médecine/Sciences, December 2015
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DOI | 10.1051/medsci/20153112011 |
Pubmed ID | |
Authors |
Marine Adlanmerini, Aurélie Fabre, Frédéric Boudou, Élodie Riant, Coralie Fontaine, Henrik Laurell, Pierre Gourdy, Françoise Lenfant, Jean-François Arnal |
Abstract |
Estrogen receptors (ER) are used as therapeutic targets, either for contraception or for the hormonal replacement therapy in menopausal women, but also in physiopathology for breast cancer treatment. It is therefore important to understand the tissue-specificity of the actions of ERα to optimize the benefits/risks ratio in each tissue. Besides the conventional nuclear ERα acting as a transcription factor, many studies have demonstrated that ERα is also able to mediate extra nuclear signaling, enabling rapid actions of estrogen. Recently, new transgenic mouse models were used to study these effects, and allowed to genetically segregate membrane versus nuclear actions of a steroid hormone receptor, demonstrating their in vivo tissue-specific roles. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 17% |
Unspecified | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 5 | 42% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 17% |
Agricultural and Biological Sciences | 2 | 17% |
Unspecified | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Unknown | 6 | 50% |