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Tissue-specific membrane effects of estrogen receptor alpha

Overview of attention for article published in Médecine/Sciences, December 2015
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Title
Tissue-specific membrane effects of estrogen receptor alpha
Published in
Médecine/Sciences, December 2015
DOI 10.1051/medsci/20153112011
Pubmed ID
Authors

Marine Adlanmerini, Aurélie Fabre, Frédéric Boudou, Élodie Riant, Coralie Fontaine, Henrik Laurell, Pierre Gourdy, Françoise Lenfant, Jean-François Arnal

Abstract

Estrogen receptors (ER) are used as therapeutic targets, either for contraception or for the hormonal replacement therapy in menopausal women, but also in physiopathology for breast cancer treatment. It is therefore important to understand the tissue-specificity of the actions of ERα to optimize the benefits/risks ratio in each tissue. Besides the conventional nuclear ERα acting as a transcription factor, many studies have demonstrated that ERα is also able to mediate extra nuclear signaling, enabling rapid actions of estrogen. Recently, new transgenic mouse models were used to study these effects, and allowed to genetically segregate membrane versus nuclear actions of a steroid hormone receptor, demonstrating their in vivo tissue-specific roles.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 17%
Unspecified 1 8%
Student > Bachelor 1 8%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 5 42%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 17%
Agricultural and Biological Sciences 2 17%
Unspecified 1 8%
Immunology and Microbiology 1 8%
Unknown 6 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#22,760,732
of 25,377,790 outputs
Outputs from Médecine/Sciences
#2,009
of 2,176 outputs
Outputs of similar age
#338,329
of 395,917 outputs
Outputs of similar age from Médecine/Sciences
#19
of 21 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,176 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,917 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.