| Title |
Serum 25-hydroxyvitamin D levels and incident falls in older women
|
|---|---|
| Published in |
Osteoporosis International, September 2018
|
| DOI | 10.1007/s00198-018-4705-4 |
| Pubmed ID | |
| Authors |
K. Uusi-Rasi, R. Patil, S. Karinkanta, K. Tokola, P. Kannus, C. Lamberg-Allardt, H. Sievänen |
| Abstract |
Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk. Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women. Given large individual variation in individual responses, we assessed here effects of S-25(OH)D levels on fall incidence. Irrespective of original group allocation, data from 387 women were explored in quartiles by mean S-25(OH)D levels over 6-24 months; means (SD) were 59.3 (7.2), 74.5 (3.3), 85.7 (3.5), and 105.3 (10.9) nmol/L. Falls were recorded monthly with diaries. Physical functioning and bone density were assessed annually. Negative binomial regression was used to assess incidence rate ratios (IRRs) for falls and Cox-regression to assess hazard ratios (HR) for fallers. Generalized linear models were used to test between-quartile differences in physical functioning and bone density with the lowest quartile as reference. There were 37% fewer falls in the highest quartile, while the two middle quartiles did not differ from reference. The respective IRRs (95% CI) for falls were 0.63 (0.44 to 0.90), 0.78 (0.55 to 1.10), and 0.87 (0.62 to 1.22), indicating lower falls incidence with increasing mean S-25(OH)D levels. There were 42% fewer fallers (HR 0.58; 040 to 0.83) in the highest quartile compared to reference. Physical functioning did not differ between quartiles. Falls and faller rates were about 40% lower in the highest S-25(OH)D quartile despite similar physical functioning in all quartiles. Prevalent S-25(OH)D levels may influence individual fall risk. Individual responses to vitamin D treatment should be considered in falls prevention. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 3 | 50% |
| Netherlands | 1 | 17% |
| United States | 1 | 17% |
| Canada | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
| Members of the public | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 14% |
| Student > Bachelor | 14 | 14% |
| Student > Ph. D. Student | 7 | 7% |
| Researcher | 6 | 6% |
| Other | 5 | 5% |
| Other | 25 | 25% |
| Unknown | 30 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 20 | 20% |
| Medicine and Dentistry | 17 | 17% |
| Sports and Recreations | 7 | 7% |
| Unspecified | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 12 | 12% |
| Unknown | 37 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2018.
All research outputs
#7,062,623
of 23,105,443 outputs
Outputs from Osteoporosis International
#1,248
of 3,673 outputs
Outputs of similar age
#125,199
of 341,066 outputs
Outputs of similar age from Osteoporosis International
#16
of 46 outputs
Altmetric has tracked 23,105,443 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,673 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,066 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.