Title |
A Temporal Association between Accumulated Petrol (Gasoline) Lead Emissions and Motor Neuron Disease in Australia
|
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Published in |
International Journal of Environmental Research and Public Health, December 2015
|
DOI | 10.3390/ijerph121215047 |
Pubmed ID | |
Authors |
Mark A. S. Laidlaw, Dominic B. Rowe, Andrew S. Ball, Howard W. Mielke |
Abstract |
The age standardised death rate from motor neuron disease (MND) has increased from 1.29 to 2.74 per 100,000, an increase of 112.4% between 1959 and 2013. It is clear that genetics could not have played a causal role in the increased rate of MND deaths over such a short time span. We postulate that environmental factors are responsible for this rate increase. We focus on lead additives in Australian petrol as a possible contributing environmental factor. The associations between historical petrol lead emissions and MND death trends in Australia between 1962 and 2013 were examined using linear regressions. Regression results indicate best fit correlations between a 20 year lag of petrol lead emissions and age-standardised female death rate (R² = 0.86, p = 4.88 × 10(-23)), male age standardised death rate (R² = 0.86, p = 9.4 × 10(-23)) and percent all cause death attributed to MND (R² = 0.98, p = 2.6 × 10(-44)). Legacy petrol lead emissions are associated with increased MND death trends in Australia. Further examination of the 20 year lag between exposure to petrol lead and the onset of MND is warranted. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 4 | 57% |
United States | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 14% |
Professor | 5 | 14% |
Student > Master | 5 | 14% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 3 | 8% |
Other | 4 | 11% |
Unknown | 9 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Environmental Science | 4 | 11% |
Neuroscience | 4 | 11% |
Medicine and Dentistry | 4 | 11% |
Nursing and Health Professions | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 8 | 22% |
Unknown | 11 | 31% |