| Title |
Isothiocyanates: a class of bioactive metabolites with chemopreventive potential
|
|---|---|
| Published in |
Tumor Biology, April 2015
|
| DOI | 10.1007/s13277-015-3391-5 |
| Pubmed ID | |
| Authors |
Gaurav Kumar, Hardeep Singh Tuli, Sonam Mittal, Jitendra Kumar Shandilya, Anil Tiwari, Sardul Singh Sandhu |
| Abstract |
In recent years, growing interest has been focused on the field of chemoprevention using natural therapies. The reason to turn toward "natural" remedies is associated with diverse beneficial pharmacological properties of natural compounds. Isothiocyanates (ITCs), the major pharmacological active constituents of cruciferous vegetables, are derived from the enzymatic hydrolysis of glucosinolates (GSLs). ITCs govern many intracellular targets including cytochrome P 450 (CYP) enzymes, proteins involved in antioxidant response, tumorigenesis, apoptosis, cell cycle, and metastasis. Investigation of the mechanisms of anti-cancer drugs has given important information regarding the use of natural chemopreventive compounds. This extensive review covers various molecular aspects of the interactions of ITCs with their recognized cellular targets involved in cancer treatment in order to enhance anti-tumor outcome with decreased toxicity to patients. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 17% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 8 | 13% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Postgraduate | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 24% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Chemistry | 4 | 6% |
| Nursing and Health Professions | 3 | 5% |
| Other | 10 | 16% |
| Unknown | 19 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2019.
All research outputs
#1,728,779
of 23,314,015 outputs
Outputs from Tumor Biology
#21
of 2,635 outputs
Outputs of similar age
#23,717
of 265,245 outputs
Outputs of similar age from Tumor Biology
#2
of 151 outputs
Altmetric has tracked 23,314,015 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,635 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,245 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.