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Associations of maternal and fetal 25‐hydroxyvitamin D levels with childhood eczema: The Generation R Study

Overview of attention for article published in Pediatric Allergy & Immunology, January 2016
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Title
Associations of maternal and fetal 25‐hydroxyvitamin D levels with childhood eczema: The Generation R Study
Published in
Pediatric Allergy & Immunology, January 2016
DOI 10.1111/pai.12530
Pubmed ID
Authors

Tatjana Gazibara, Niels J Elbert, Herman T den Dekker, Johan C de Jongste, Irwin Reiss, John J McGrath, Darryl W Eyles, Thomas H Burne, Henning Tiemeier, Vincent W V Jaddoe, Suzanne G M A Pasmans, Liesbeth Duijts

Abstract

Exposure to low levels of vitamin D in fetal life might affect the developing immune system, and subsequently the risk of childhood eczema. We examined whether 25-hydroxyvitamin D levels in mid-gestation and at birth were associated with the risk of eczema until the age of 4 years. In a population-based prospective cohort study of 3,019 mothers and their children, maternal blood samples in mid-gestation and umbilical cord blood samples at birth were used to determine 25-hydroxyvitamin D levels (severely deficient <25.0 nmol/L, deficient 25.0-49.9 nmol/L, sufficient 50.0-74.9 nmol/L, optimal ≥75.0 nmol/L). Eczema was prospectively assessed by annual questionnaires until the age of 4 years. Eczema patterns included never, early (age ≤1 year only), late (age >1 year only), and persistent eczema (age ≤ and >1 year). Data were assessed using generalized estimating equations and multinomial regression models. Compared with the optimal 25-hydroxyvitamin D group, sufficient, deficient and severely deficient groups of 25-hydroxyvitamin D level in mid-gestation were not associated with the risk of overall eczema (odds ratios (95%confidence interval): 1.09 (0.82, 1.43), 1.04 (0.87, 1.25) and 0.94 (0.81, 1.10), p-values for trend >0.05), nor with eczema per year or eczema patterns in children up to the age of 4 years. Similarly, we observed no associations of 25-hydroxyvitamin D groups at birth with any eczema outcome. Our results suggest that levels of 25-hydroxyvitamin D in mid-gestation and at birth are not associated with the risk of overall eczema, eczema per year or eczema patterns among children until the age of 4 years. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 12%
Student > Master 5 12%
Student > Bachelor 4 9%
Researcher 4 9%
Student > Ph. D. Student 4 9%
Other 8 19%
Unknown 13 30%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Nursing and Health Professions 5 12%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 3 7%
Computer Science 1 2%
Other 3 7%
Unknown 15 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2015.
All research outputs
#8,295,322
of 25,654,806 outputs
Outputs from Pediatric Allergy & Immunology
#1,127
of 2,263 outputs
Outputs of similar age
#124,192
of 404,863 outputs
Outputs of similar age from Pediatric Allergy & Immunology
#21
of 34 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,263 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,863 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.