| Title |
Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex
|
|---|---|
| Published in |
Brain Structure and Function, December 2015
|
| DOI | 10.1007/s00429-015-1166-9 |
| Pubmed ID | |
| Authors |
Márton Rózsa, Judith Baka, Sándor Bordé, Balázs Rózsa, Gergely Katona, Gábor Tamás |
| Abstract |
Communication between individual GABAergic cells and their target neurons is mediated by synapses and, in the case of neurogliaform cells (NGFCs), by unitary volume transmission. Effects of non-synaptic volume transmission might involve non-neuronal targets, and astrocytes not receiving GABAergic synapses but expressing GABA receptors are suitable for evaluating this hypothesis. Testing several cortical interneuron types in slices of the rat cerebral cortex, we show selective unitary transmission from NGFCs to astrocytes with an early, GABAA receptor and GABA transporter-mediated component and a late component that results from the activation of GABA transporters and neuronal GABAB receptors. We could not detect Ca(2+) influx in astrocytes associated with unitary GABAergic responses. Our experiments identify a presynaptic cell-type-specific, GABA-mediated communication pathway from individual neurons to astrocytes, assigning a role for unitary volume transmission in the control of ionic and neurotransmitter homeostasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| United States | 1 | 2% |
| Unknown | 54 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 33% |
| Researcher | 8 | 14% |
| Student > Master | 7 | 12% |
| Other | 3 | 5% |
| Professor | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 14 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 40% |
| Agricultural and Biological Sciences | 12 | 21% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Medicine and Dentistry | 2 | 4% |
| Computer Science | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 12 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2020.
All research outputs
#6,946,007
of 24,217,893 outputs
Outputs from Brain Structure and Function
#522
of 1,725 outputs
Outputs of similar age
#105,217
of 396,682 outputs
Outputs of similar age from Brain Structure and Function
#13
of 34 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,682 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.